ArticleJMIR research protocols2022
Lessons From a Rapid Project Management Exercise in the Time of Pandemic: Methodology for a Global COVID-19 VIRUS Registry Database.
Article in JMIR research protocols, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04323787 (Viral Infection and Respiratory Illness Universal Study[VIRUS]), which is not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Viral Infection and Respiratory Illness Universal Study[VIRUS]: COVID-19 Registry and Validation of C2D2 (Critical Care Data Dictionary)
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Mortality and Severity in COVID-19 Patients on ACEIs and ARBs-A Systematic Review, Meta-Analysis, and Meta-Regression Analysis.Frontiers in medicine · 2021Pooled it
- Article
- Association Between Ethnicity and Mortality Outcomes in Patients with COVID-19: A Mayo Clinic VIRUS Registry Cohort Study.Journal of racial and ethnic health disparities · 2025Article
- Clinical Research Network: JHCRN Infrastructure and Lessons Learned.Clinical and translational science · 2025Review
- Article
- Modeling solutions for microbial water contamination in the global south for public health protection.Frontiers in microbiology · 2025Review
- Role of Procalcitonin as a Prognostic Biomarker in Hospitalized COVID-19 Patients: A Comparative Analysis.Biomarker insights · 2025Article
- Hospital and Temporal Variations in Limitations of Care Among Hospitalized Patients with COVID-19: A VIRUS Registry Retrospective Cohort Study.Palliative medicine reports · 2025Article
- Violence study of healthcare workers and systems in the Caribbean: ViSHWaS-Caribbean study.World journal of methodology · 2024Article
- Optimising Clinical Epidemiology in Disease Outbreaks: Analysis of ISARIC-WHO COVID-19 Case Report Form Utilisation.Epidemiologia (Basel, Switzerland) · 2024Article
- Guiding principles for the conduct of the Violence Study of Healthcare Workers and System (ViSHWaS): Insights from a global survey.Journal of global health · 2024Article
- ViSHWaS: Violence Study of Healthcare Workers and Systems-a global survey.BMJ global health · 2023Article
- Development and Validation of an Acute Respiratory Distress Syndrome Prediction Model in Coronavirus Disease 2019: Updated Lung Injury Prediction Score.Mayo Clinic proceedings · 2023Article
- The impact of violence on healthcare workers' mental health in conflict based settings amidst COVID-19 pandemic, and potential interventions: A narrative review.Health science reports · 2022Article
- Association of latitude and altitude with adverse outcomes in patients with COVID-19: The VIRUS registry.World journal of critical care medicine · 2022Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe rapid emergence of the COVID-19 pandemic globally collapsed health care organizations worldwide. Incomplete knowledge of best practices, progression of disease, and its impact could result in fallible care. Data on symptoms and advancement of the SARS-CoV-2 virus leading to critical care admission have not been captured or communicated well between international organizations experiencing the same impact from the virus. This led to the expedited need for establishing international communication and data collection on the critical care patients admitted with COVID-19.
objectiveDeveloping a global registry to collect patient data in the critical care setting was imperative with the goal of analyzing and ameliorating outcomes.
methodsA prospective, observational global registry database was put together to record extensive deidentified clinical information for patients hospitalized with COVID-19.
resultsProject management was crucial for prompt implementation of the registry for synchronization, improving efficiency, increasing innovation, and fostering global collaboration for valuable data collection. The Society of Critical Care Medicine Discovery VIRUS (Viral Infection and Respiratory Illness Universal Study): COVID-19 Registry would compile data for crucial longitudinal outcomes for disease, treatment, and research. The agile project management approach expedited establishing the registry in 15 days and submission of institutional review board agreement for 250 participating sites. There has been enrollment of sites every month with a total of 306 sites from 28 countries and 64,114 patients enrolled (as of June 7, 2021).
conclusionsThis protocol addresses project management lessons in a time of crises which can be a precept for rapid project management for a large-scale health care data registry. We aim to discuss the approach and methodology for establishing the registry, the challenges faced, and the factors contributing to successful outcomes.
trial registrationClinicalTrials.gov NCT04323787; https://clinicaltrials.gov/ct2/show/NCT04323787.
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