Evidence map›Paper›PMID 34762039›Full record

ArticleJournal of studies on alcohol and drugs2021

Substance Use, PTSD Symptoms, and Suicidal Ideation Among Veteran Psychiatry Inpatients: A Latent Class Trajectory Analysis.

Noel A Vest, Fernanda S Rossi, Mark Ilgen, Keith Humphreys, Christine Timko

Abstract read
In one paragraph

Article in Journal of studies on alcohol and drugs, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Noel A VestDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California.
Fernanda S RossiDepartment of Veterans Affairs, Center for Innovation to Implementation, Veterans Affairs Palo Alto Health Care System, Menlo Park, California.
Mark IlgenUniversity of Michigan Department of Psychiatry, Ann Arbor, Michigan.
Keith HumphreysDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California.
Christine TimkoDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California.

Funding

Interdisciplinary Research Training in Pain and Substance Use DisordersT32DA035165 · NIDA · STANFORD UNIVERSITY · PI SEAN C MACKEY · 2013 to 2026
$7.2M
HSRD VA IAC 09-055HSRD VA RCS 00-001HSRD VA RCS 14-232NIDA NIH HHS T32 DA035165
6 · The paper itself

Abstract

objectiveIn this study, we aimed to inform clinical practice by identifying distinct subgroups of U.S. veteran psychiatry inpatients on their alcohol and drug use severity, posttraumatic stress disorder (PTSD) symptoms, and suicidal ideation over time.

methodParticipants were 406 patients with co-occurring substance use and mental health disorders. A parallel latent growth trajectory model was used to characterize participants' symptom severity across 15 months posttreatment intake.

resultsFour distinct classes were identified: 47% "normative improvement," 32% "high PTSD," 11% "high drug use," and 9% "high alcohol use." Eighty percent of the sample had reduced their drinking and drug intake by half from baseline to 3 months, and those levels remained stable from 3 to 15 months. The High PTSD, High Drug Use, and High Alcohol Use classes all reported levels of PTSD symptomatology at baseline consistent with a clinical diagnosis, and symptom levels remained high and stable across all 15 months. The Normative Improvement class showed declining drug and alcohol intake and was the only class exhibiting reductions in PTSD symptomatology over time. High substance use classes showed initial declines in suicidal ideation, then an increase from 9 to 15 months.

conclusionsThe reduction in frequency of drinking and drug use for 80% of the sample was substantial and supports the potential efficacy of current treatment approaches. However, the high and stable levels of PTSD for more than 50% of the sample, as well as the reemergence of suicidal ideation in a sizable subgroup, underscore the difficulty in finding and linking patients to effective interventions to decrease symptomatology over time.

Indexed as

PsychiatryStress Disorders, Post-TraumaticSubstance-Related DisordersVeteransHumansInpatientsSuicidal Ideation

Identifiers

PMID34762039
PMCPMC8819620

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.