Evidence map›Paper›PMID 34761908›Full record

ArticleACS chemical biology2021

Immunomodulatory Response of Toll-like Receptor Ligand-Peptide Conjugates in Food Allergy.

Jorge Losada Méndez, Francisca Palomares, Francisca Gómez, Pedro Ramírez-López, Javier Ramos-Soriano, Maria Jose Torres, Cristobalina Mayorga, Javier Rojo

Open access · hybridAbstract read
In one paragraph

Article in ACS chemical biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Metagenomic Analysis Reveals the Anti-Inflammatory Properties of Mare Milk.International journal of molecular sciences · 2025
    Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jorge Losada MéndezGlycosystems Laboratory, Instituto de Investigaciones Químicas (IIQ), CSIC─Universidad de Sevilla, 41092 Seville, Spain.
Francisca PalomaresAllergy Unit, IBIMA, Regional University Hospital of Malaga, UMA, 29009 Malaga, Spain.
Francisca GómezAllergy Clinical Unit, Hospital Regional Universitario de Málaga, 29009 Málaga, Spain.
Pedro Ramírez-LópezGlycosystems Laboratory, Instituto de Investigaciones Químicas (IIQ), CSIC─Universidad de Sevilla, 41092 Seville, Spain.
Javier Ramos-SorianoGlycosystems Laboratory, Instituto de Investigaciones Químicas (IIQ), CSIC─Universidad de Sevilla, 41092 Seville, Spain.
Maria Jose TorresAllergy Clinical Unit, Hospital Regional Universitario de Málaga, 29009 Málaga, Spain.
Cristobalina MayorgaAllergy Unit, IBIMA, Regional University Hospital of Malaga, UMA, 29009 Malaga, Spain.
Javier RojoGlycosystems Laboratory, Instituto de Investigaciones Químicas (IIQ), CSIC─Universidad de Sevilla, 41092 Seville, Spain.ORCID 0000-0003-3173-3437
Hospital Regional Universitario de Málaga · ESInstituto de Investigaciones Químicas · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Covalent conjugation of allergens to toll-like receptor (TLR) agonists appears to be a powerful strategy for the development of safety compounds for allergen-specific immunomodulatory response toward tolerance in allergy. In this work, we have synthesized two family of ligands, an 8-oxoadenine derivative as a ligand for TLR7 and a pyrimido[5,4-

Indexed as

ImmunomodulationAllergensCarrier ProteinsCell ProliferationCytokinesFood HypersensitivityHumansLigandsPeptidesT-LymphocytesToll-Like Receptor 4Toll-Like Receptor 7AllergensCarrier ProteinsCytokinesLigandslipid transfer proteinPeptidesTLR4 protein, humanToll-Like Receptor 4Toll-Like Receptor 7

Identifiers

PMID34761908
PMCPMC8609526
OpenAlexW3214203706

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.