Evidence map›Paper›PMID 34761861›Full record

ArticleChembiochem : a European journal of chemical biology2022

Selective Capture of Anti-N-glucosylated NTHi Adhesin Peptide Antibodies by a Multivalent Dextran Conjugate.

Antonio Mazzoleni, Feliciana Real-Fernandez, Francesca Nuti, Roberta Lanzillo, Vincenzo Brescia Morra, Paolo Dambruoso, Monica Bertoldo, Paolo Rovero, Jean-Maurice Mallet, Anna Maria Papini

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Antonio MazzoleniLaboratoire des Biomolécules, Département de Chimie, École Normale Supérieure, PSL University, Sorbonne Université, CNRS, 24 rue Lhomond, 75005, Paris, France.
Feliciana Real-FernandezInterdepartmental Research Unit of Peptide and Protein Chemistry and Biology, Department of Chemistry "Ugo Schiff", University of Florence, Via della Lastruccia 13, 50019, Sesto Fiorentino, Italy.
Francesca NutiInterdepartmental Research Unit of Peptide and Protein Chemistry and Biology, Department of Chemistry "Ugo Schiff", University of Florence, Via della Lastruccia 13, 50019, Sesto Fiorentino, Italy.
Roberta LanzilloMultiple Sclerosis Clinical Care and Research Centre, Department of Neurosciences, Reproductive Sciences and Odontostomatology, Federico II University, Via Pancini 5, 80131, Naples, Italy.
Vincenzo Brescia MorraMultiple Sclerosis Clinical Care and Research Centre, Department of Neurosciences, Reproductive Sciences and Odontostomatology, Federico II University, Via Pancini 5, 80131, Naples, Italy.
Paolo DambruosoISOF - Istituto per la Sintesi Organica e la Fotoreattività, Consiglio Nazionale delle Ricerche, Via Gobetti 101, 40129, Bologna, Italy.ORCID 0000-0003-3937-9671
Monica BertoldoDipartimento di Scienze chimiche, farmaceutiche ed agrarie, Università di Ferrara, Via Fossato di Mortara 17, 44121, Ferrara, Italy.
Paolo RoveroInterdepartmental Research Unit of Peptide and Protein Chemistry and Biology, Department of Neurosciences, Psychology, Drug Research and Child Health, Section of Pharmaceutical Sciences and Nutraceutics, University of Florence, Via Ugo Schiff 6, 50019, Sesto Fiorentino, Italy.ORCID 0000-0001-9577-5228
Jean-Maurice MalletLaboratoire des Biomolécules, Département de Chimie, École Normale Supérieure, PSL University, Sorbonne Université, CNRS, 24 rue Lhomond, 75005, Paris, France.
Anna Maria PapiniInterdepartmental Research Unit of Peptide and Protein Chemistry and Biology, Department of Chemistry "Ugo Schiff", University of Florence, Via della Lastruccia 13, 50019, Sesto Fiorentino, Italy.ORCID 0000-0002-2947-7107
University of Florence · ITCentre National de la Recherche Scientifique · FRFederico II University Hospital · ITUniversity of Ferrara · ITInstitute of Organic Synthesis and Photoreactivity · IT

Funding

Fondazione Ente Cassa di Risparmio Firenze 2014.0306French-Italian University C3-24Italian Multiple Sclerosis Foundation (FISM) 2017/R/5Regione Toscana 85438University of Florence
6 · The paper itself

Abstract

Tentacle-like polymers decorated with several copies of peptide antigens can be interesting tools for increasing the ability to capture circulating antibodies in patient sera, using cooperative effects for stronger avidity. We previously showed that antibodies from multiple sclerosis (MS) patient sera preferentially recognize hyperglucosylated adhesin protein HMW1ct of non-typeable Haemophilus influenzae (NTHi). We selected the C-terminal HMW1ct(1347-1354) minimal epitope and prepared the diglucosylated analogue Ac-KAN(Glc)VTLN(Glc)TTG-K(N

Indexed as

Adhesins, BacterialAnti-Bacterial AgentsAutoantibodiesDextransGlycosylationHaemophilus influenzaeHumansMicrobial Sensitivity TestsMolecular StructurePeptidesAdhesins, BacterialAnti-Bacterial AgentsAutoantibodiesDextransPeptidesantibody captiondextran conjugatesELISAmultivalencepeptides

Identifiers

PMID34761861
PMCPMC9300045
OpenAlexW3214669347

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.