Evidence map›Paper›PMID 34761825›Full record

ArticleThe Journal of physiology2022

Myofibre injury induces capillary disruption and regeneration of disorganized microvascular networks.

Nicole L Jacobsen, Charles E Norton, Rebecca L Shaw, D D W Cornelison, Steven S Segal

Open access · greenAbstract read
In one paragraph

Article in The Journal of physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Eccentric Exercise and Muscle Damage: An Introductory Guide.Journal of functional morphology and kinesiology · 2026
    Review
  5. Review
  6. Article
  7. Review
  8. Pericytes in mouse heart.Frontiers in physiology · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Signaling roles of platelets in skeletal muscle regeneration.BioEssays : news and reviews in molecular, cellular and developmental biology · 2023
    Article
  13. Article
  14. Review
  15. Microvascular Skeletal-Muscle Crosstalk in Health and Disease.International journal of molecular sciences · 2023
    Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Nicole L JacobsenMedical Pharmacology and Physiology, University of Missouri, Columbia, MO, USA.ORCID 0000-0003-1860-4585
Charles E NortonMedical Pharmacology and Physiology, University of Missouri, Columbia, MO, USA.ORCID 0000-0001-9442-4039
Rebecca L ShawMedical Pharmacology and Physiology, University of Missouri, Columbia, MO, USA.
D D W CornelisonBiological Sciences, University of Missouri, Columbia, MO, USA.ORCID 0000-0003-4287-7524
Steven S SegalMedical Pharmacology and Physiology, University of Missouri, Columbia, MO, USA.ORCID 0000-0001-5667-2154
University of Missouri · US

Funding

Intercellular Coordination of Blood Flow ControlR37HL041026 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI SEGAL, STEVEN S · 2008 to 2018
$3.7M
Ephrin-A3 Specifies Slow Muscle Fiber TypeR01AR067450 · NIAMS · UNIVERSITY OF MISSOURI-COLUMBIA · PI CORNELISON, DAWN D · 2014 to 2020
$1.9M
Role of satellite cells in microvascular recovery during skeletal muscle regenerationF32HL152558 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI JACOBSEN, NICOLE LYNNE · 2021 to 2022
$140k
NHLBI NIH HHS F32 HL152558NHLBI NIH HHS R37 HL041026NIAMS NIH HHS R01 AR067450
6 · The paper itself

Abstract

Injury to skeletal muscle disrupts myofibres and their microvascular supply. While the regeneration of myofibres is well described, little is known of how the microcirculation is affected by skeletal muscle injury or its recovery during regeneration. Nevertheless, the microvasculature must also recover to restore skeletal muscle function. We aimed to define the nature of microvascular damage and time course of repair during muscle injury and regeneration induced by the myotoxin BaCl

Indexed as

CapillariesEndothelial CellsAnimalsMiceMice, Inbred C57BLMicrovesselsMuscle, SkeletalRegenerationcapillariesmicrocirculationmyofibreskeletal muscle regeneration

Identifiers

PMID34761825
PMCPMC8965732
OpenAlexW3213457829

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.