ArticleThe Journal of physiology2021
Lactate ions induce synaptic plasticity to enhance output from the central respiratory network.
Article in The Journal of physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Lactate Changes Quantified by fMRS: A Meta-Analysis.NMR in biomedicine · 2026Pooled it
- Brain-derived ketone bodies can replace glucose to power neural function.bioRxiv : the preprint server for biology · 2026Article
- Beyond Fuel: Exercise-Induced Lactate as a Metabolic-Epigenetic Regulator in Central Nervous System Health and Disease.Biomolecules · 2025Review
- Lactate links exercise to synaptic protection and cognitive enhancement in Alzheimer's disease models.BMC medicine · 2025Article
- Plasticity in voltage-gated ion channels following overwintering in respiratory motoneurons of American bullfrogs.The Journal of experimental biology · 2025Article
- Temperature-Induced Seasonal Dynamics of Brain Gangliosides in Rainbow Trout (Life (Basel, Switzerland) · 2024Article
- Evaluation of sex-based differences in central control of breathing in American bullfrogs.Respiratory physiology & neurobiology · 2024Article
- Plasticity in the Functional Properties of NMDA Receptors Improves Network Stability during Severe Energy Stress.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Impact of NLRP3 Depletion on Aging-Related Metaflammation, Cognitive Function, and Social Behavior in Mice.International journal of molecular sciences · 2023Article
- BDNF and Lactate as Modulators of Hippocampal CA3 Network Physiology.Cellular and molecular neurobiology · 2023Review
- Plasticity in the functional properties of NMDA receptors improves network stability during severe energy stress.bioRxiv : the preprint server for biology · 2023Article
- Article
- Inactivity and CaScientific reports · 2022Article
- A brainstem preparation allowing simultaneous access to respiratory motor output and cellular properties of motoneurons in American bullfrogs.The Journal of experimental biology · 2022Article
- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Lactate ion sensing has emerged as a process that regulates ventilation during metabolic challenges. Most work has focused on peripheral sensing of lactate for the control of breathing. However, lactate also rises in the central nervous system (CNS) during disturbances to blood gas homeostasis and exercise. Using an amphibian model, we recently showed that lactate ions, independently of pH and pyruvate metabolism, act directly in the brainstem to increase respiratory-related motor outflow. This response had a long washout time and corresponded with potentiated excitatory synaptic strength of respiratory motoneurons. Thus, we tested the hypothesis that lactate ions enhance respiratory output using cellular mechanisms associated with long-term synaptic plasticity within motoneurons. In this study, we confirm that 2 mM sodium lactate, but not sodium pyruvate, increases respiratory motor output in brainstem-spinal cord preparations, persisting for 2 h upon the removal of lactate. Lactate also led to prolonged increases in the amplitude of AMPA-glutamate receptor (AMPAR) currents in individual motoneurons from brainstem slices. Both motor facilitation and AMPAR potentiation by lactate required classic effectors of synaptic plasticity, L-type Ca
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.