Evidence map›Paper›PMID 34761556›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2022

Structures of Class I and Class II Transcription Complexes Reveal the Molecular Basis of RamA-Dependent Transcription Activation.

Min Hao, Fuzhou Ye, Milija Jovanovic, Ioly Kotta-Loizou, Qingqing Xu, Xiaohua Qin, Martin Buck, Xiaodong Zhang, Minggui Wang

Open access · goldAbstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. mSystems · 2025
    Article
  3. Article
  4. Transcription activation inEcoSal Plus · 2024
    Review
  5. Dual role ofiMetaOmics · 2024
    Article
  6. Article
  7. Structural insights into the transcription activation mechanism of the global regulator GlnR from actinobacteria.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  8. Mapping direct and indirect MarA/SoxS/Rob/RamA regulons inMicrobiology (Reading, England) · 2023
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Min HaoInstitute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Fuzhou YeSection of Structural Biology, Department of Infectious Diseases, Imperial College London, London, SW7 2AZ, UK.
Milija JovanovicDepartment of Life Sciences, Imperial College London, London, SW7 2AZ, UK.
Ioly Kotta-LoizouDepartment of Life Sciences, Imperial College London, London, SW7 2AZ, UK.
Qingqing XuInstitute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Xiaohua QinInstitute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Martin BuckDepartment of Life Sciences, Imperial College London, London, SW7 2AZ, UK.
Xiaodong ZhangSection of Structural Biology, Department of Infectious Diseases, Imperial College London, London, SW7 2AZ, UK.
Minggui WangInstitute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, 200040, China.ORCID 0000-0001-7682-5859
Imperial College London · GBFudan University · CN

Funding

Biotechnology and Biological Sciences Research Council BB/N007816/1China International Medical Foundation Z-2018-35-2003Medical Research Council MR/N006828/1Medical Research Council MR/P007503/1Medical Research Council MR/S014934/1National Natural Science Foundation of China 81401699National Natural Science Foundation of China 81773785National Natural Science Foundation of China 81991531
6 · The paper itself

Abstract

Transcription activator RamA is linked to multidrug resistance of Klebsiella pneumoniae through controlling genes that encode efflux pumps (acrA) and porin-regulating antisense RNA (micF). In bacteria, σ

Indexed as

Anti-Bacterial AgentsBacterial ProteinsDrug Resistance, Multiple, BacterialKlebsiella pneumoniaeTrans-ActivatorsTranscriptional ActivationTranscription FactorsAnti-Bacterial AgentsBacterial ProteinsRamA protein, KlebsiellaTrans-ActivatorsTranscription Factorsantibiotic resistanceclass I and class II activatorscryoEM structuresRamARNAP-σ70

Identifiers

PMID34761556
PMCPMC8811837
OpenAlexW3212298837

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.