Evidence map›Paper›PMID 34761545›Full record

ArticleThe clinical respiratory journal2022

What are the factors affecting the recovery rate of bronchoalveolar lavage fluid?

Kohei Shikano, Mitsuhiro Abe, Yuki Shiko, Kenji Tsushima, Keiichiro Yoshioka, Tsukasa Ishiwata, Takeshi Kawasaki, Jun Ikari, Jiro Terada, Yohei Kawasaki and 1 more

Open access · hybridAbstract read
In one paragraph

Article in The clinical respiratory journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Trial
  2. Evaluation of ICAM and VCAM as biomarkers in serum and bronchoscopic lavage samples of lung cancer patients.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Article
  3. Genes required forbioRxiv : the preprint server for biology · 2025
    Article
  4. Article
  5. Serial Bronchoalveolar Lavage FluidOpen forum infectious diseases · 2024
    Article
  6. Article
  7. Article
  8. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Kohei ShikanoDepartment of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan.ORCID https://orcid.org/0000-0001-8781-2367
Mitsuhiro AbeDepartment of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan.ORCID https://orcid.org/0000-0001-9084-3180
Yuki ShikoBiostatistics Section, Clinical Research Center, Chiba University Hospital, Chiba, Japan.ORCID https://orcid.org/0000-0002-3959-9343
Kenji TsushimaDepartment of Pulmonary Medicine, School of Medicine, International University of Health and Welfare, Chiba, Japan.ORCID https://orcid.org/0000-0003-4095-133X
Keiichiro YoshiokaDepartment of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan.ORCID https://orcid.org/0000-0001-9844-9794
Tsukasa IshiwataDepartment of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan.ORCID https://orcid.org/0000-0003-2369-2698
Takeshi KawasakiDepartment of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan.ORCID https://orcid.org/0000-0002-1468-172X
Jun IkariDepartment of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan.ORCID https://orcid.org/0000-0001-7750-4328
Jiro TeradaDepartment of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan.ORCID https://orcid.org/0000-0001-9019-4053
Yohei KawasakiBiostatistics Section, Clinical Research Center, Chiba University Hospital, Chiba, Japan.ORCID https://orcid.org/0000-0002-7474-7647
Koichiro TatsumiDepartment of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan.ORCID https://orcid.org/0000-0001-9484-7912
Chiba University · JPChiba University Hospital · JPInternational University of Health and Welfare · JP

Funding

Japan Society for the Promotion of Science JP19K20727
6 · The paper itself

Abstract

backgroundBronchoalveolar lavage (BAL) is a useful examination for the evaluation of interstitial lung disease. A high BAL fluid (BALF) recovery rate is desirable because low recovery rates lead to inaccurate diagnoses and increased adverse events. Few studies have explored whether BALF recovery rates are influenced by clinical factors.

objectivesThis study aimed to identify the clinical parameters affecting the recovery rates of BALF and the extent of their effects.

methodData from patients who underwent BAL at the Chiba University Hospital between 2013 and 2019 were retrospectively reviewed. BAL was performed with three aliquots of 50-ml physiological saline. The potential association of the BALF recovery rate with clinical parameters such as age, sex, smoking status, underlying disease, bronchus used for the procedure and pulmonary function, was analysed.

resultsEight hundred twenty-six patients had undergone BAL. The average recovery rate was 52.4%. Factors affecting BALF recovery rates included male sex (odds ratio [OR]: 0.32, 95% confidence interval [CI]: 0.20-0.53, p < 0.001); age ≥ 65 years (OR: 0.50, 95% CI: 0.33-0.76, p < 0.001); use of the left bronchus (OR: 0.46, 95% CI: 0.30-0.71, p = 0.001) and bronchi other than the middle lobe bronchus or lingula (OR: 0.41, 95% CI: 0.25-0.65, p < 0.001); and forced expiratory volume in 1 s divided by forced vital capacity <80% (OR: 0.42, 95% CI: 0.40-1.00, p < 0.001).

conclusionSex, age, bronchus used for the procedure and pulmonary function may be useful as pre-procedural predictors of BALF recovery rates.

Indexed as

Lung Diseases, InterstitialAgedBronchoalveolar LavageBronchoalveolar Lavage FluidHumansMaleRespiratory Function TestsRetrospective Studiesbronchoalveolar lavagebronchoscopyinterstitial lung diseaselung functionspirometry

Identifiers

PMID34761545
PMCPMC9060131
OpenAlexW3211562924

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.