Evidence map›Paper›PMID 34761340›Full record

ArticleJournal of gastrointestinal cancer2022

Predictive Outcomes Using Child-Turcotte-Pugh and Albumin-Bilirubin Scores in Patients with Hepatocellular Carcinoma Undergoing Transarterial Chemoembolization.

Keerati Akarapatima, Arunchai Chang, Tanaporn Prateepchaiboon, Nuttanit Pungpipattrakul, Apiradee Songjamrat, Songklod Pakdeejit, Attapon Rattanasupar, Teerha Piratvisuth

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Article in Journal of gastrointestinal cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

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0cells of the map it votes in
6citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Keerati AkarapatimaDivision of Gastroenterology, Department of Internal Medicine, Hatyai Hospital, Songkhla, 90110, Thailand.
Arunchai ChangDivision of Gastroenterology, Department of Internal Medicine, Hatyai Hospital, Songkhla, 90110, Thailand. busmdcu58@gmail.com.ORCID http://orcid.org/0000-0002-0158-2685
Tanaporn PrateepchaiboonDepartment of Internal Medicine, Hatyai Hospital, Songkhla, Thailand.
Nuttanit PungpipattrakulDepartment of Internal Medicine, Hatyai Hospital, Songkhla, Thailand.
Apiradee SongjamratDivision of Intervention Radiology, Department of Radiology, Hatyai Hospital, Songkhla, Thailand.
Songklod PakdeejitDivision of Intervention Radiology, Department of Radiology, Hatyai Hospital, Songkhla, Thailand.
Attapon RattanasuparDivision of Gastroenterology, Department of Internal Medicine, Hatyai Hospital, Songkhla, 90110, Thailand.
Teerha PiratvisuthNKC Institute of Gastroenterology and Hepatology, Faculty of Medicine, Songklanagarind Hospital, Prince of Songkhla University, Songkhla, Thailand.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionWe assessed the ability of the Child-Turcotte-Pugh score and the albumin-bilirubin grade to predict the outcomes of hepatocellular carcinoma (HCC) in patients treated with transarterial chemoembolization.

methodsWe retrospectively assessed 158 patients with HCC who underwent transarterial chemoembolization. The ability of the Child-Turcotte-Pugh score and the albumin-bilirubin grade to predict patient survival was assessed using the Kaplan-Meier method. The Cox proportional hazards model was used to evaluate survival-predictive variables and the relationship between the obtained score and overall survival.

resultsChild-Turcotte-Pugh A (n = 102 (64.6%)) patients showed better overall survival than Child-Turcotte-Pugh B (n = 56 (35.4%)) patients (log-rank P = 0.017), while no significant difference in the overall survival between albumin-bilirubin ≤ 1 (n = 37 (23.4%)) and albumin-bilirubin > 1 (n = 121 (76.6%)) was detected (log-rank P = 0.140). Multivariate analysis identified alcoholic liver disease (P = 0.029), tumor size > 5 cm (P = 0.004), and serum alpha-fetoprotein > 200 ng/mL (P < 0.001) as independent predictive factors of mortality risk. A higher Child-Turcotte-Pugh score was positively associated with decreased overall survival (P = 0.031); however, a higher albumin-bilirubin grade showed marginally significant association (P = 0.088).

conclusionsThe Child-Turcotte-Pugh score precisely categorized the outcomes of HCC in patients undergoing transarterial chemoembolization, and cirrhotic patients with Child-Turcotte-Pugh A will have a better overall survival than those with Child-Turcotte-Pugh B, regardless of HCC status. These results suggest that the Child-Turcotte-Pugh classification system is a more powerful tool to predict patient outcomes than the albumin-bilirubin grading system.

Indexed as

Carcinoma, HepatocellularChemoembolization, TherapeuticLiver NeoplasmsAlbuminsBilirubinBiomarkers, TumorHumansPrognosisRetrospective StudiesSerum Albumin, HumanTreatment OutcomeAlbuminsBilirubinBiomarkers, TumorSerum Albumin, HumanAlbumin–bilirubinChild–Turcotte–PughHepatocellular carcinomaOverall survivalTransarterial chemoembolization

Identifiers

PMID34761340

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.