Evidence map›Paper›PMID 34761183›Full record

ArticleiScience2021

Large-scale voltage imaging in behaving mice using targeted illumination.

Sheng Xiao, Eric Lowet, Howard J Gritton, Pierre Fabris, Yangyang Wang, Jack Sherman, Rebecca A Mount, Hua-An Tseng, Heng-Ye Man, Christoph Straub and 4 more

Abstract read
In one paragraph

Article in iScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Voltage Imaging with Periodic Structured Illumination.bioRxiv : the preprint server for biology · 2025
    Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Sheng XiaoDepartment of Biomedical Engineering, Boston University, Boston, MA 02215, USA.
Eric LowetDepartment of Biomedical Engineering, Boston University, Boston, MA 02215, USA.
Howard J GrittonDepartment of Biomedical Engineering, Boston University, Boston, MA 02215, USA.
Pierre FabrisDepartment of Biomedical Engineering, Boston University, Boston, MA 02215, USA.
Yangyang WangDepartment of Biomedical Engineering, Boston University, Boston, MA 02215, USA.
Jack ShermanDepartment of Biomedical Engineering, Boston University, Boston, MA 02215, USA.
Rebecca A MountDepartment of Biomedical Engineering, Boston University, Boston, MA 02215, USA.
Hua-An TsengDepartment of Biomedical Engineering, Boston University, Boston, MA 02215, USA.
Heng-Ye ManDepartment of Biology, Boston University, Boston, MA 02215, USA.
Christoph StraubDepartment of Biomedical Sciences, College of Osteopathic Medicine, University of New England, Biddeford, ME 04005, USA.
Kiryl D PiatkevichSchool of Life Sciences, Westlake University, Westlake Laboratory of Life Sciences and Biomedicine, Westlake Institute for Advanced Study, Hangzhou, Zhejiang, China.
Edward S BoydenMIT McGovern Institute for Brain Research, MIT, Cambridge, MA 02139, USA.
Jerome MertzDepartment of Biomedical Engineering, Boston University, Boston, MA 02215, USA.
Xue HanDepartment of Biomedical Engineering, Boston University, Boston, MA 02215, USA.

Funding

TRAINING IN BIOMOLECULAR PHARMACOLOGYT32GM008541 · NIGMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI FARB, DAVID H · 1997 to 2022
$5.2M
Unveiling the mechanisms of ultrasound neuromodulation via spatially confined stimulation and temporally resolved recordingR01NS109794 · NINDS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI CHENG, JI-XIN, HAN, XUE · 2018 to 2022
$3.6M
Multidimensional Optimization of Voltage Indicators for In Vivo Neural Activity ImagingR01MH122971 · NIMH · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI HAN, XUE · 2020 to 2024
$3.4M
Voltage Imaging Analysis of Striatal Network Dynamics Related to Movement, Parkinson's Disease and Deep Brain StimulationR01NS115797 · NINDS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI HAN, XUE · 2020 to 2024
$2.3M
Fast, large-scale neuronal imaging with multi-z confocal microscopyR01EB029171 · NIBIB · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI MERTZ, JEROME · 2020 to 2023
$1.8M
Cortical Spatial Processing for Solving the Cocktail Party ProblemR34NS111742 · NINDS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI HAN, XUE, SEN, KAMAL K · 2019 to 2019
$720k
Mechanistic study of the role of autism spectrum disorder risk genes in hippocampal CA1 population dynamics during learning and memoryF31MH123008 · NIMH · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI MOUNT, REBECCA · 2021 to 2023
$86k
NIBIB NIH HHS R01 EB029171NIGMS NIH HHS T32 GM008541NIMH NIH HHS F31 MH123008NIMH NIH HHS R01 MH122971NINDS NIH HHS R01 NS109794NINDS NIH HHS R01 NS115797NINDS NIH HHS R34 NS111742
6 · The paper itself

Abstract

Recent improvements in genetically encoded voltage indicators enabled optical imaging of action potentials and subthreshold transmembrane voltage

Indexed as

NeuroscienceOptical imagingTechniques in neuroscience

Identifiers

PMID34761183
PMCPMC8567393

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.