Evidence map›Paper›PMID 34761174›Full record

ReviewFASEB bioAdvances2021

In vivo imaging of EVs in zebrafish: New perspectives from "the waterside".

Vincenzo Verdi, Anaïs Bécot, Guillaume van Niel, Frederik J Verweij

Abstract readReview
In one paragraph

Review in FASEB bioAdvances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Vincenzo VerdiINSERM U1266 Institut de Psychiatrie et Neurosciences de Paris Paris France.ORCID https://orcid.org/0000-0002-7963-5732
Anaïs BécotINSERM U1266 Institut de Psychiatrie et Neurosciences de Paris Paris France.ORCID https://orcid.org/0000-0001-7574-2680
Guillaume van NielINSERM U1266 Institut de Psychiatrie et Neurosciences de Paris Paris France.ORCID https://orcid.org/0000-0002-8651-9705
Frederik J VerweijINSERM U1266 Institut de Psychiatrie et Neurosciences de Paris Paris France.ORCID https://orcid.org/0000-0001-8879-1174

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To harmoniously coordinate the activities of all its different cell types, a multicellular organism critically depends on intercellular communication. One recently discovered mode of intercellular cross-talk is based on the exchange of "extracellular vesicles" (EVs). EVs are nano-sized heterogeneous lipid bilayer vesicles enriched in a variety of biomolecules that mediate short- and long-distance communication between different cells, and between cells and their environment. Numerous studies have demonstrated important aspects pertaining to the dynamics of their release, their uptake, and sub-cellular fate and roles in vitro. However, to demonstrate these and other aspects of EV biology in a relevant, fully physiological context in vivo remains challenging. In this review we analyze the state of the art of EV imaging in vivo, focusing in particular on zebrafish as a promising model to visualize, study, and characterize endogenous EVs in real-time and expand our understanding of EV biology at cellular and systems level.

Indexed as

exosomesextracellular vesicleshomeostasislive‐imagingzebrafish

Identifiers

PMID34761174
PMCPMC8565201

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.