Evidence map›Paper›PMID 34761149›Full record

ArticleJBMR plus2021

Romosozumab Followed by Antiresorptive Treatment Increases the Probability of Achieving Bone Mineral Density Treatment Goals.

Felicia Cosman, Cesar Libanati, Cynthia Deignan, Zhigang Yu, Zhenxun Wang, Serge Ferrari, Jens-Erik Beck Jensen, Pilar Peris, Francesco Bertoldo, Eric Lespessailles and 2 more

Abstract read
In one paragraph

Article in JBMR plus, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Probability of achieving bone mineral density treatment targets with abaloparatide and teriparatide.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025
    Trial
  2. Probability of achieving bone mineral density treatment goals with denosumab treatment in postmenopausal women with osteoporosis.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025
    Trial
  3. Romosozumab followed by denosumab versus denosumab only: a post hoc analysis of FRAME and FRAME extension.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024
    Trial
  4. Observational
  5. Review
  6. A new age of osteoanabolic therapy? A real-world, two-centre study comparing effects of romosozumab, teriparatide, and antiresorptive therapies for osteoporosis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Goal-directed osteoporosis treatment: ASBMR/BHOF task force position statement 2024.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Felicia CosmanColumbia University New York NY USA.ORCID https://orcid.org/0000-0003-4554-6616
Cesar LibanatiUCB Pharma Brussels Belgium.ORCID https://orcid.org/0000-0003-1427-7839
Cynthia DeignanAmgen Inc Thousand Oaks CA USA.
Zhigang YuAmgen Inc Thousand Oaks CA USA.
Zhenxun WangAmgen Inc Thousand Oaks CA USA.
Serge FerrariGeneva University Hospital Geneva Switzerland.ORCID https://orcid.org/0000-0002-1372-4417
Jens-Erik Beck JensenCopenhagen University Hospital Hvidovre Denmark.
Pilar PerisHospital Clinic, IDIBAPS University of Barcelona Barcelona Spain.
Francesco BertoldoUniversity of Verona Verona Italy.
Eric LespessaillesCentre Hospitalier Régional d'Orléans University of Orléans Orleans France.
Eric HesseInstitute of Molecular Musculoskeletal Research University Hospital, LudwigMaximilians-University Munich Germany.
Steven R CummingsUniversity of California San Francisco San Francisco Coordinating Center San Francisco CA USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Increases in bone mineral density (BMD) with osteoporosis treatment are associated with reduced fracture risk. Increasing BMD is therefore a goal of osteoporosis therapy. Here, we compare the probability of achieving a

Indexed as

ANABOLICSANTIRESORPTIVESCLINICAL TRIALSDXAOSTEOPOROSIS

Identifiers

PMID34761149
PMCPMC8567484

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.