ArticlePractical laboratory medicine2021
Frequency of icteric interference in clinical chemistry laboratory tests and causes of severe icterus.
Article in Practical laboratory medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 14 citations in OpenAlex.
- Development and Evaluation of Artificial Intelligence-Based Two-Step Model for Automated Serum Quality Assessment in Clinical Laboratories.Annals of laboratory medicine · 2026Article
- Optimization of icterus interference thresholds for 45 parameters on the Atellica analyzers CH930 and IM1300.Biochemia medica · 2026Article
- Preliminary investigation of circulating methaemoglobin fraction in cats with sepsis: a small exploratory study.Journal of feline medicine and surgery · 2026Article
- Can the icteric index be used instead of total bilirubin in addition to being a preanalytical marker? Icteric index in the laboratory.Practical laboratory medicine · 2025Article
- Article
- Definition of icteric interference index for six biochemical analytes.Biochemia medica · 2023Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe aims of this study were to identify the causes of severe icterus in an academic medical center patient population and to assess the impact of icterus on clinical chemistry testing using assay package insert thresholds.
design
resultsSpecimen icteric index exceeded package insert icteric index thresholds in 0.14% of clinical chemistry assays, with the highest number of instances for creatinine (1358 samples, 0.6% of total tests), total protein (1194 samples, 2.2%), and ammonia (161 samples, 3.9%). The 57 patients with an icteric index of 40 or higher accounted for 49.7% of all instances where the icteric index exceeded the specific assay package insert limit. The most common etiologies of this group of 57 patients were alcohol-related liver disease (34 patients), biliary tract disease (7 patients), and neoplasms (6 patients).
conclusionsApproximately half of all instances where specimen icteric index exceeded assay package insert thresholds occurred in a small cohort of patients with severe liver/biliary tract disease.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.