Evidence map›Paper›PMID 34760997›Full record

ArticleERJ open research2021

Dynamic contrast-enhanced magnetic resonance imaging of the lung reveals important pathobiology in idiopathic pulmonary fibrosis.

Sydney B Montesi, Iris Y Zhou, Lloyd L Liang, Subba R Digumarthy, Sarah Mercaldo, Nathaniel Mercaldo, Ravi T Seethamraju, Bruce R Rosen, Peter Caravan

Open access · goldAbstract read
In one paragraph

Article in ERJ open research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 14 citations in OpenAlex.

  1. Dual αAmerican journal of respiratory and critical care medicine · 2025
    Trial
  2. Article
  3. Molecular Imaging of Pulmonary Fibrosis.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Approach to Clinical Trials for the Prevention of Pulmonary Fibrosis.Annals of the American Thoracic Society · 2023
    Article
  10. Lung functional imaging.Breathe (Sheffield, England) · 2023
    Article
  11. Article
  12. The Vasculature in Pulmonary Fibrosis.Current tissue microenvironment reports · 2022
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Sydney B MontesiDivision of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston, MA, USA.
Iris Y ZhouInstitute for Innovation in Imaging, Massachusetts General Hospital, Boston, MA, USA.
Lloyd L LiangDivision of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston, MA, USA.
Subba R DigumarthyHarvard Medical School, Boston, MA, USA.
Sarah MercaldoDept of Radiology, Massachusetts General Hospital, Boston, MA, USA.
Nathaniel MercaldoDept of Neurology, Massachusetts General Hospital, Boston, MA, USA.
Ravi T SeethamrajuSiemens Healthcare, Boston, MA, USA.ORCID https://orcid.org/0000-0002-2719-6854
Bruce R RosenHarvard Medical School, Boston, MA, USA.
Peter CaravanInstitute for Innovation in Imaging, Massachusetts General Hospital, Boston, MA, USA.
Harvard University · USMassachusetts General Hospital · USSiemens Healthcare (United States) · US

Funding

PET Imaging of Pulmonary FibrosisR01HL131907 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI CARAVAN, PETER D, LANUTI, MICHAEL · 2016 to 2018
$2.3M
Vascular Leak and Outcomes in IPFK23HL150331 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI MONTESI, SYDNEY · 2020 to 2024
$887k
Quantitative MRI-PET Imaging of Pulmonary FibrosisK25HL148837 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI ZHOU, IRIS YUWEN · 2020 to 2023
$686k
NHLBI NIH HHS K23 HL150331NHLBI NIH HHS K25 HL148837NHLBI NIH HHS R01 HL131907
6 · The paper itself

Abstract

introductionEvidence suggests that abnormalities occur in the lung microvasculature in idiopathic pulmonary fibrosis (IPF). We hypothesised that dynamic contrast-enhanced (DCE)-magnetic resonance imaging (MRI) could detect alterations in permeability, perfusion and extracellular extravascular volume in IPF, thus providing

methodsHealthy controls and IPF subjects underwent DCE-MRI of the thorax using a dynamic volumetric radial sampling sequence and administration of gadoterate meglumine at a dose of 0.1 mmol·kg

resultsIPF subjects (n=16, 56% male, age (range) 67.5 (60-79) years) had significantly reduced peak enhancement and slower k

conclusionsDCE-MRI detects changes in the microvasculature and extravascular extracellular space in IPF, thus providing

Identifiers

PMID34760997
PMCPMC8573229
OpenAlexW3197449231

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.