Evidence map›Paper›PMID 34760967›Full record

ArticleHepatobiliary surgery and nutrition2021

Transarterial infusion chemotherapy with FOLFOX for advanced hepatocellular carcinoma: a multi-center propensity score matched analysis of real-world practice.

Shaohua Li, Jie Mei, Qiaoxuan Wang, Feng Shi, Hongyan Liu, Ming Zhao, Lianghe Lu, Yihong Ling, Zhixing Guo, Yabing Guo and 5 more

Open access · diamondAbstract read
In one paragraph

Article in Hepatobiliary surgery and nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 3 pooled it
2.2field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 1 country.

Shaohua LiDepartment of Liver Surgery, Sun Yat-sen University Cancer Center, Guangzhou, China.
Jie MeiDepartment of Liver Surgery, Sun Yat-sen University Cancer Center, Guangzhou, China.
Qiaoxuan WangState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.
Feng ShiDepartment of Interventional Radiology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Hongyan LiuState Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Ming ZhaoState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.
Lianghe LuDepartment of Liver Surgery, Sun Yat-sen University Cancer Center, Guangzhou, China.
Yihong LingState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.
Zhixing GuoState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.
Yabing GuoState Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Xiaoming ChenDepartment of Interventional Radiology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Ming ShiDepartment of Liver Surgery, Sun Yat-sen University Cancer Center, Guangzhou, China.
Wan Yee LauFaculty of Medicine, the Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China.
Wei WeiDepartment of Liver Surgery, Sun Yat-sen University Cancer Center, Guangzhou, China.
Rongping GuoDepartment of Liver Surgery, Sun Yat-sen University Cancer Center, Guangzhou, China.
Sun Yat-sen University Cancer Center · CNSun Yat-sen University · CNGuangdong Provincial People's Hospital · CNNanfang Hospital · CNState Key Laboratory of Oncology in South ChinaChinese University of Hong Kong · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo compare the treatment effectiveness and safety among transarterial infusion chemotherapy (TAI) with FOLFOX regimen, transarterial chemoembolization (TACE), and sorafenib in patients with BCLC stage C hepatocellular carcinoma (HCC).

methodsThe data of consecutive patients with BCLC stage C HCC treated with TAI, TACE, or sorafenib from January 2015 to December 2018 at three centers were retrospectively analyzed. Propensity-score matched (PSM) analysis was pairwise performed to reduce selection bias. Treatment effectiveness and safety were evaluated and compared using the Kaplan-Meier method, log-rank test, Cox regression models, and χ

resultsThe median overall survival (OS) in the matched TAI cohort was significantly longer than the sorafenib cohort (19.6

conclusionsTAI with FOLFOX regimen was an effective and safe therapy that improved survival of patients with BCLC stage C HCC.

Indexed as

FOLFOXHepatocellular carcinoma (HCC)sorafenibtransarterial chemoembolizationtransarterial infusion chemotherapy

Identifiers

PMID34760967
PMCPMC8527433
OpenAlexW3019665438

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.