Evidence map›Paper›PMID 34760912›Full record

ArticleFrontiers in nutrition2021

Associations of Human Milk Oligosaccharides With Otitis Media and Lower and Upper Respiratory Tract Infections up to 2 Years: The Ulm SPATZ Health Study.

Linda P Siziba, Marko Mank, Bernd Stahl, Deborah Kurz, John Gonsalves, Bernadet Blijenberg, Dietrich Rothenbacher, Jon Genuneit

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Frontiers in nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07050693 (Efficacy of A 2'-Fucosylactose-based Food Supplement on the Prevention of Respiratory and Gastrointestinal Infections in Schhol-attended Children), which is not on this map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07050693 narecruitingnot on this mapstarted 2025, after this paper: background citation

Efficacy of A 2'-Fucosylactose-based Food Supplement on the Prevention of Respiratory and Gastrointestinal Infections in Schhol-attended Children: a Randomized, Double-blind, Placebo-controlled Trial.

TypeinterventionalSponsorUniversity of BariRan2025 to 2026Enrolled100ConditionsGastroenteric Tract, Respiratory Tract, Infections, Gastroenteric InfectionsArmsVitamin + Zinc + micronutrient mixture, Placebo
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 2 countries.

Linda P SizibaDepartment of Pediatrics, Pediatric Epidemiology, Medical Faculty, Leipzig University, Leipzig, Germany.
Marko MankDanone Nutricia Research, Utrecht, Netherlands.
Bernd StahlDanone Nutricia Research, Utrecht, Netherlands.
Deborah KurzInstitute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany.
John GonsalvesDanone Nutricia Research, Utrecht, Netherlands.
Bernadet BlijenbergDanone Nutricia Research, Utrecht, Netherlands.
Dietrich RothenbacherInstitute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany.
Jon GenuneitDepartment of Pediatrics, Pediatric Epidemiology, Medical Faculty, Leipzig University, Leipzig, Germany.
Danone Nutricia Research (Netherlands)Universität Ulm · DELeipzig University · DENutricia Research (Netherlands) · NLUtrecht University · NLZimmer Biomet (Germany) · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

human milk groupshuman milk oligosaccharides (HMOs)lower respiratory tract infections (LRTI)otitis media (OM)targeted LC-MS/MS2upper respiratory tract infections (URTI)

Identifiers

PMID34760912
PMCPMC8572796
OpenAlexW3208652940

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.