Evidence map›Paper›PMID 34760800›Full record

ArticleJournal of International Society of Preventive & Community Dentistry

Clinicopathological Correlation of Cyclooxygenase 2 Expression in Oral Submucous Fibrosis: An Immunohistochemical Study.

Catakapatri Venugopal Divyambika, Sankarapandian Sathasivasubramanian, Shyamsundar Vidyarani, Austin RaviDavid, Srinivasan Harinee, Ramshankar Vijayalakshmi

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of International Society of Preventive & Community Dentistry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Catakapatri Venugopal DivyambikaDepartment of Oral Medicine and Radiology, Faculty of Dental Sciences, Sri Ramachandra Institute of Higher Education and Research (Deemed to be University), Chennai, India.
Sankarapandian SathasivasubramanianDepartment of Oral Medicine and Radiology, Faculty of Dental Sciences, Sri Ramachandra Institute of Higher Education and Research (Deemed to be University), Chennai, India.
Shyamsundar VidyaraniCentre for Oral Cancer Prevention, Awareness and Research, Sree Balaji Dental College and Hospital, BIHER University, Pallikaranai, Chennai, India.
Austin RaviDavidDepartment of Oral Medicine and Radiology, Rajah Muthiah Dental College, Annamalai University, Chidambaram, India.
Srinivasan HarineeDepartment of Oral Medicine and Radiology, Faculty of Dental Sciences, Sri Ramachandra Institute of Higher Education and Research (Deemed to be University), Chennai, India.
Ramshankar VijayalakshmiDepartment of Preventive Oncology (Research), Cancer Institute WIA, Adyar, Chennai, Tamil Nadu, India.
Sri Ramachandra Institute of Higher Education and Research · INAnnamalai University · INCancer Institute (WIA) · INSree Balaji Dental College and Hospital · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOral submucous fibrosis (OSMF) has a high prevalence in Southeast Asia with increased malignant transformation rates. Numerous biomarkers are currently being investigated to predict the disease prognosis and for early detection of malignant changes. MATERIALS AND

methodsA prospective study was conducted comprising 40 subjects with clinically and biopsy-proven OSMF being included in the study as experimental group (

resultsBased on IHC expression of COX 2, all the patients of the control group were negative for COX 2, and among the OSMF group, 19 patients (67.9%) were positive and 9 patients (32.1%) were found to be negative for COX 2. The association of COX2 expression on comparison of controls with OSMF was found to be statistically significant (

conclusionThe significant expression of COX 2 in different clinical stages of OSMF when compared with normal shows the role of COX 2 in the pathogenesis of OSMF and could serve as a potent biomarker for assessing the disease progression.

Indexed as

Cyclooxygenase 2immunohistochemistrymalignant transformationoral submucous fibrosis

Identifiers

PMID34760800
PMCPMC8533033
OpenAlexW3207360408

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.