Evidence map›Paper›PMID 34760715›Full record

ArticleFrontiers in cellular and infection microbiology2021

Gut Microbiota and Fecal Metabolites Associated With Neurocognitive Impairment in HIV-Infected Population.

Ruihua Dong, Haijiang Lin, Xiaoxiao Chen, Ruizi Shi, Shiying Yuan, Jing Li, Bowen Zhu, Xiaohui Xu, Weiwei Shen, Keran Wang and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

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  14. Intestinal Microbiota Dysbiosis Promotes Mucosal Barrier Damage and Immune Injury in HIV-Infected Patients.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Ruihua DongDepartment of Nutrition and Food Hygiene, School of Public Health, Fudan University, Shanghai, China.
Haijiang LinDepartment of Epidemiology, School of Public Health and The Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, China.
Xiaoxiao ChenDepartment of Epidemiology, Taizhou City Center for Disease Control and Prevention, Taizhou, China.
Ruizi ShiDepartment of Epidemiology, School of Public Health and The Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, China.
Shiying YuanDepartment of Epidemiology, School of Public Health and The Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, China.
Jing LiDepartment of Epidemiology, School of Public Health and The Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, China.
Bowen ZhuDepartment of Epidemiology, School of Public Health and The Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, China.
Xiaohui XuDepartment of Epidemiology, School of Public Health and The Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, China.
Weiwei ShenDepartment of Epidemiology, Taizhou City Center for Disease Control and Prevention, Taizhou, China.
Keran WangDepartment of Epidemiology, School of Public Health and The Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, China.
Xiao-Ou ShuDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN, United States.
Ding DingInstitute of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Na HeDepartment of Epidemiology, School of Public Health and The Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, China.
Fudan University · CNHuashan Hospital · CNVanderbilt University Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gut microbiota dysbiosis has been associated with many neurological diseases. However, how microbiota composition and metabolism relate to neurocognitive impairment (NCI) in HIV-infected individuals is largely unknown. In this study, a total of 102 HIV infected participants were classified into two groups-those with NCI and those without-using the global deficit score (GDS). Fecal samples were collected from the participants for 16S rRNA gene sequencing and untargeted metabolomics. The plasma level of 25 hydroxy-vitamin D (25(OH)D) was also evaluated. Although α-diversity and β-diversity were comparable, the HIV patients with NCI were significantly different from those without NCI in terms of abundance of several gut microbiota. The decreased abundance of butyrate-producing bacteria (BPB) and increased abundance of

Indexed as

Gastrointestinal MicrobiomeHIV InfectionsCarotid Intima-Media ThicknessFecesHumansRNA, Ribosomal, 16SRNA, Ribosomal, 16Sbutyrate-producing bacteriagut microbiotaHIVmetabolomicsneurocognitive impairment (NCI)vitamin D

Identifiers

PMID34760715
PMCPMC8574817
OpenAlexW3209910975

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.