ArticleChemical science2021
A comprehensive analysis in one run - in-depth conformation studies of protein-polymer chimeras by asymmetrical flow field-flow fractionation.
Article in Chemical science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Disc-Toroid Hybrid Lipid Nanoparticles for Efficient Drug Encapsulation and Subcutaneous Delivery.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Role of Polymer Backbone Rigidity on the Solution Properties of Bioderived Poly(styrene-ACS polymers Au · 2026Article
- Combinatorial Synthesis of Protein-Polymer Conjugates by Postpolymerization Modification of Poly(pentafluorophenyl acrylate)s.ACS omega · 2026Article
- Site-Specific Polymer-Protein-Polymer Conjugates for the Preparation of Dual Responsive Multilayer Nanoparticles.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Artificial Zymogen Based on Protein-Polymer Hybrids.Biomacromolecules · 2024Article
- Tailored Branched Polymer-Protein Bioconjugates for Tunable Sieving Performance.ACS macro letters · 2024Article
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Authors and funding
6 authors.
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Abstract
Polymer-based protein engineering has enabled the synthesis of a variety of protein-polymer conjugates that are widely applicable in therapeutic, diagnostic and biotechnological industries. Accurate characterizations of physical-chemical properties, in particular, molar masses, sizes, composition and their dispersities are critical parameters that determine the functionality and conformation of protein-polymer conjugates and are important for creating reproducible manufacturing processes. Most of the current characterization techniques suffer from fundamental limitations and do not provide an accurate understanding of a sample's true nature. In this paper, we demonstrate the advantage of asymmetrical flow field-flow fractionation (AF4) coupled with multiple detectors for the characterization of a library of complex, zwitterionic and neutral protein-polymer conjugates. This method allows for determination of intrinsic physical properties of protein-polymer chimeras from a single, rapid measurement.
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Registered trials
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