Evidence map›Paper›PMID 34760152›Full record

ArticleChemical science2021

Molecular basis for acyl carrier protein-ketoreductase interaction in

Munro Passmore, Angelo Gallo, Józef R Lewandowski, Matthew Jenner

Open access · diamondAbstract read
In one paragraph

Article in Chemical science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Munro PassmoreDepartment of Chemistry, University of Warwick Coventry CV4 7AL UK m.jenner@warwick.ac.uk.ORCID https://orcid.org/0000-0002-7065-9682
Angelo GalloDepartment of Chemistry, University of Warwick Coventry CV4 7AL UK m.jenner@warwick.ac.uk.ORCID https://orcid.org/0000-0001-9778-4822
Józef R LewandowskiDepartment of Chemistry, University of Warwick Coventry CV4 7AL UK m.jenner@warwick.ac.uk.ORCID https://orcid.org/0000-0001-6525-7083
Matthew JennerDepartment of Chemistry, University of Warwick Coventry CV4 7AL UK m.jenner@warwick.ac.uk.ORCID https://orcid.org/0000-0003-2317-3011
University of Warwick · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The biosynthesis of polyketides by type I modular polyketide synthases (PKS) relies on co-ordinated interactions between acyl carrier protein (ACP) domains and catalytic domains within the megasynthase. Despite the importance of these interactions, and their implications for biosynthetic engineering efforts, they remain poorly understood. Here, we report the molecular details of the interaction interface between an ACP domain and a ketoreductase (KR) domain from a

Identifiers

PMID34760152
PMCPMC8549798
OpenAlexW3202102092

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.