Evidence map›Paper›PMID 34760077›Full record

ArticleDental research journal2021

Regeneration of dentin-pulp complex by using dental pulp stem cells in dog.

Fatemeh Dehghani Nazhvani, Setareh Kazempour, Seyed-Mojtaba Hosseini, Ali Dehghani Nazhvani, Pardis Haddadi

Open access · goldAbstract read
PubMed Full text at PMC
In one paragraph

Article in Dental research journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Frontiers in veterinary science · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Fatemeh Dehghani NazhvaniBone and Joint Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Setareh KazempourResearch Committee, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
Seyed-Mojtaba HosseiniResearch Committee, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Ali Dehghani NazhvaniDepartment of Oral and Maxillofacial Pathology, Biomaterials Research Center, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
Pardis HaddadiDepartment of Periodontology, School of Dentistry, Lorestan University of Medical Sciences, Khorramabad, Iran.
Shiraz University of Medical Sciences · IRLorestan University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAlthough missing tooth is not life-threatening, it affects the quality of daily life. Stem cells have emerged as an important player in the generation and maintenance of many tissues. The role of scaffolds has changed from a passive carrier to a bioactive matrix, which can be used to induce cellular behavior. The aim of this study was to determine the possibility of regeneration of dentin-pulp complex with dental pulp stem cells (DPSCs) in an animal model. MATERIALS AND

methodsIn this animal study after extraction of DPSCs and cultivation, 10 types of scaffolds were made by using platelet-rich plasma (PRP), cancellous bone, and collagen pad. They were inserted in different parts of the dog's mouth. After the 4

resultsMicroscopic examination revealed no sign of cell differentiation and formation of new structures in those models which used collagen scaffolds. However, the dentin-pulp complex emerged in models that the combination of bone scaffolds and PRP or stem cells was used.

conclusionUsing bone scaffolds in combination with PRP or DPSCs to regenerate dentin-pulp complex in dog helped odontoblastic and pulpal differentiation as well as the formation of predentin and tubular dentin.

Indexed as

Complexdental pulp stem celldentindifferentiationplatelet-rich plasmapulp

Identifiers

PMID34760077
PMCPMC8554473
OpenAlexW3205744255

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.