Evidence map›Paper›PMID 34760006›Full record

ArticleResearch in pharmaceutical sciences2021

Design of a chitosan-based nano vaccine against epsilon toxin of

Farnaz Poorhassan, Fahimeh Nemati, Parvaneh Saffarian, Seyed Ali Mirhosseini, Mohammad Javad Motamedi

Open access · goldAbstract read
In one paragraph

Article in Research in pharmaceutical sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. The efficacy of egg albumin nanoparticles adjuvanted Clostridium perfringens type D toxoid vaccine in rabbits.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025
    Article
  3. Effect ofNAM journal · 2025
    Article
  4. Review
  5. Article
  6. Frontiers in veterinary science · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Farnaz PoorhassanDepartment of Biology, School of Basic Sciences, Science and Research Branch, Islamic Azad University, Tehran, I.R. Iran.
Fahimeh NematiDepartment of Biotechnology, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, I.R. Iran.
Parvaneh SaffarianDepartment of Biology, School of Basic Sciences, Science and Research Branch, Islamic Azad University, Tehran, I.R. Iran.
Seyed Ali MirhosseiniApplied Microbiology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, I.R. Iran.
Mohammad Javad MotamediMolecular Biology Department, Green Gene Company, Tehran, I.R. Iran.
Islamic Azad University, Science and Research Branch · IRBaqiyatallah University of Medical Sciences · IRIslamic Azad University Medical Branch of Tehran · IRStem Cell Technology Research Center · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeEXPERIMENTAL APPROACH: The FINDINGS/

resultsThe results of ELISA showed that IgA antibody serum level increased sufficiently using recombinant protein with nanoparticle as an oral and injectable formulation. IgG antibody titers increased significantly after administrating the recombinant proteins with nanoparticles through both oral delivery and intravenous injection. CONCLUSION AND IMPLICATION: In conclusion, the recombinant ETX is suggested as a good candidate for vaccine production against diseases caused by ETX of

Indexed as

ChitosanClostridium perfringensEpsilon toxinImmunizationNano-vaccine

Identifiers

PMID34760006
PMCPMC8562408
OpenAlexW3207029257

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.