Evidence map›Paper›PMID 34759890›Full record

ArticleFrontiers in endocrinology2021

PACAP-PAC1 Signaling Regulates Serotonin 2A Receptor Internalization.

Atsuko Hayata-Takano, Yusuke Shintani, Keita Moriguchi, Naoki Encho, Kohei Kitagawa, Takanobu Nakazawa, Hitoshi Hashimoto

Open access · goldAbstract read
In one paragraph

Article in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. PACInternational journal of molecular sciences · 2022
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Atsuko Hayata-TakanoLaboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Japan.
Yusuke ShintaniLaboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Japan.
Keita MoriguchiLaboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Japan.
Naoki EnchoLaboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Japan.
Kohei KitagawaLaboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Japan.
Takanobu NakazawaLaboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Japan.
Hitoshi HashimotoLaboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Japan.
Osaka University · JPChiba University · JPHamamatsu University School of Medicine · JPTokyo University of Agriculture · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mice lacking pituitary adenylate cyclase-activating polypeptide (PACAP) display psychomotor abnormalities, most of which are ameliorated by atypical antipsychotics with serotonin (5-HT) 2A receptor (5-HT

Indexed as

AnimalsCells, CulturedHEK293 CellsHumansMiceMice, Inbred ICRMice, KnockoutNeuronsPituitary Adenylate Cyclase-Activating PolypeptideProtein TransportReceptor, Serotonin, 5-HT2AReceptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type ISignal TransductionAdcyap1 protein, mousePituitary Adenylate Cyclase-Activating PolypeptideReceptor, Serotonin, 5-HT2AReceptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type IG protein-coupled receptor (GPCR)hallucinationinternalizationpituitary adenylate cyclase-activating polypeptide (PACAP)serotonin 2A receptor (5-HT2A)β-arrestin

Identifiers

PMID34759890
PMCPMC8574227
OpenAlexW3211016258

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.