Evidence map›Paper›PMID 34759825›Full record

ArticleFrontiers in pharmacology2021

Antiviral and Immunomodulatory Effects of

Jan Papies, Jackson Emanuel, Nicolas Heinemann, Žarko Kulić, Simon Schroeder, Beate Tenner, Martin D Lehner, Georg Seifert, Marcel A Müller

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Review
  7. Immunomodulatory Effects ofExpert reviews in molecular medicine · 2025
    Review
  8. Article
  9. Article
  10. Article
  11. Long-term benefits of EPsFrontiers in pharmacology · 2024
    Article
  12. Article
  13. Review
  14. EPsInternational journal of molecular sciences · 2023
    Article
  15. Article
  16. Article
  17. Frontiers in pharmacology · 2023
    Article
  18. Safety ofFrontiers in pediatrics · 2023
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Jan PapiesInstitute of Virology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
Jackson EmanuelInstitute of Virology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
Nicolas HeinemannInstitute of Virology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
Žarko KulićPreclinical R & D, Dr. Willmar Schwabe GmbH & Co. KG, Karlsruhe, Germany.
Simon SchroederInstitute of Virology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
Beate TennerInstitute of Virology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
Martin D LehnerPreclinical R & D, Dr. Willmar Schwabe GmbH & Co. KG, Karlsruhe, Germany.
Georg SeifertDepartment of Paediatric Oncology/Haematology, Otto-Heubner Centre for Paediatric and Adolescent Medicine (OHC), Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Marcel A MüllerInstitute of Virology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
Freie Universität Berlin · DEDr Willmar Schwabe (Germany) · DECharité - Universitätsmedizin Berlin · DEGerman Center for Infection Research · DEHumboldt-Universität zu Berlin · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Treatment options for COVID-19 are currently limited. Drugs reducing both viral loads and SARS-CoV-2-induced inflammatory responses would be ideal candidates for COVID-19 therapeutics. Previous

Indexed as

antiviralscoronavirusCOVID-19cytokine stormpelargonium root extract (EPs® 7630)phytomedicineSARS-CoV-2

Identifiers

PMID34759825
PMCPMC8573200
OpenAlexW3210574513

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.