ArticleSaudi journal of biological sciences2021
Study of optimal conditions for growth and osteogenic differentiation of dental pulp stem cells based on glucose and serum content.
Article in Saudi journal of biological sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed, 7 citations in OpenAlex.
- Article
- Osteogenic Potential of a Three-Phase Strontium- and Silicon-Doped Tricalcium Silicate Cement on Dental Pulp Stem Cells: An In Vitro Study.Clinical and experimental dental research · 2026Article
- Engineering a cell-free bone regeneration platform using osteogenically primed MSC-EVs and nHAp-enriched IPN hydrogels.Regenerative medicine · 2025Article
- Fructose vs. glucose: modulating stem cell growth and function through sugar supplementation.FEBS open bio · 2024Article
- Research progress on optimization ofFrontiers in bioengineering and biotechnology · 2024Review
- Mitochondrial reactive oxygen species promote mitochondrial damage in high glucose-induced dysfunction and apoptosis of human dental pulp cells.Journal of dental sciences · 2024Article
- Advances in combined application of dental stem cells and small-molecule drugs in regenerative medicine.Human cell · 2023Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dental pulp stem cells (DPSCs) have shown promising characteristics in terms of their proliferation and osteogenic differentiation potential, which could be of greater benefit in regenerative dentistry. However, obstacles remain in the in vitro cultivation of DPSCs, which significantly affect their growth and differentiating ability. Therefore in this study, we demonstrated the growth and osteogenic differentiation of DPSCs in the presence of media containing different combinations of serum and glucose to get an optimized combination of both. DPSCs were cultured in media containing combinations of low glucose (LG), low serum (LS), high glucose (HG), and high serum (HS). The proliferation and osteogenic differentiation were assessed in DPSCs cultured with these different combinations of culture conditions. High glucose high serum condition significantly inhibited the proliferation of DPSCs and also affected their clonogenic potential, as evidenced by colony-forming units. Irrespective of the serum content, high glucose in the media also decreased the osteogenic potential of DPSCs confirmed by functional staining, and downregulation of osteogenesis-related genes. High glucose content in the culture media affects the growth and differentiation potential of the DPSCs. Hence, the culture conditions for the DPSCs should be reconsidered to utilize their maximum potential.
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Registered trials
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