ArticleNature structural & molecular biology2021
Structural basis and mechanism of activation of two different families of G proteins by the same GPCR.
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Article in Nature structural & molecular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
What it found
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Who cites it
25 citing papers in PubMed, 52 citations in OpenAlex.
- Structural basis and physiological significance of non-canonical GNature communications · 2026Article
- Structural insights into single-pass transmembrane receptor GC-A activation by distinct antihypertensive antibodies.Nature communications · 2026Article
- The beta1-adrenergic receptor in the heart.Cell death discovery · 2025Review
- Dissociation kinetics of G proteins from G protein-coupled receptors and effects of allosteric modulation.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Enhanced Sampling and Tailored Collective Variables Yield Reproducible Free Energy Landscapes of Beta-1 Adrenergic Receptor Activation.Journal of chemical theory and computation · 2025Article
- The structural basis of the G protein-coupled receptor and ion channel axis.Current research in structural biology · 2025Review
- Molecular and functional profiling of Gαi as an intracellular pH sensor.Nature communications · 2025Article
- Architecture and activation of single-pass transmembrane receptor guanylyl cyclase.Nature structural & molecular biology · 2025Article
- The pharmacogenomic landscape in the Chinese: An analytics of pharmacogenetic variants in 206,640 individuals.Innovation (Cambridge (Mass.)) · 2025Article
- Coupling and Activation of the β1 Adrenergic Receptor - The Role of the Third Intracellular Loop.Journal of the American Chemical Society · 2024Article
- Distinct binding conformations of epinephrine with α- and β-adrenergic receptors.Experimental & molecular medicine · 2024Article
- Optical control of cell-surface and endomembrane-exclusive β-adrenergic receptor signaling.The Journal of biological chemistry · 2024Article
- Bayesian network models identify cooperative GPCR:G protein interactions that contribute to G protein coupling.The Journal of biological chemistry · 2024Article
- Molecular Determinant Underlying Selective Coupling of Primary G-Protein by Class A GPCRs.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Optical Control of Cell-Surface and Endomembrane-Exclusive β-Adrenergic Receptor Signaling.bioRxiv : the preprint server for biology · 2024Article
- Binding kinetics drive G protein subtype selectivity at the βNature communications · 2024Article
- Structural titration reveals CaNature communications · 2023Article
- Bayesian network models identify co-operative GPCR:G protein interactions that contribute to G protein coupling.bioRxiv : the preprint server for biology · 2023Article
- Structural basis of agonist specificity of αNature communications · 2023Article
- New insights into GPCR coupling and dimerisation from cryo-EM structures.Current opinion in structural biology · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Kamela O Alegre *Department of Physiology and Biophysics, Weill Cornell Medical College of Cornell University, New York, NY, USA.
Navid Paknejad *Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0001-8914-7604
Minfei Su *Department of Physiology and Biophysics, Weill Cornell Medical College of Cornell University, New York, NY, USA.
Jian-Shu LouDepartment of Physiology and Biophysics, Weill Cornell Medical College of Cornell University, New York, NY, USA.
Jianyun HuangDepartment of Physiology and Biophysics, Weill Cornell Medical College of Cornell University, New York, NY, USA.
Kelsey D JordanSimons Electron Microscopy Center, National Resource for Automated Molecular Microscopy, New York Structural Biology Center, New York, NY, USA.
Edward T EngSimons Electron Microscopy Center, National Resource for Automated Molecular Microscopy, New York Structural Biology Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-8014-7269
Joel R MeyersonDepartment of Physiology and Biophysics, Weill Cornell Medical College of Cornell University, New York, NY, USA.
Richard K HiteStructural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. hiter@mskcc.org.ORCID http://orcid.org/0000-0003-0496-0669
Xin-Yun HuangDepartment of Physiology and Biophysics, Weill Cornell Medical College of Cornell University, New York, NY, USA. xyhuang@med.cornell.edu.ORCID http://orcid.org/0000-0003-2534-2587
Cornell University · USMemorial Sloan Kettering Cancer Center · USNew York Structural Biology Center · US
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4MTRD #3: An automated and streamlined pipeline for in-situ molecular microscopyP41GM103310 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI DE MARCO, ALEX, KIEFT, JEFFREY S · 2012 to 2021
$14.7MMolecular characterization of the multi-modal regulation of inositol 1,4,5-trisphosphate receptorsR01GM132307 · NIGMS · SLOAN-KETTERING INST CAN RESEARCH · PI HITE, RICHARD KEVIN · 2019 to 2023
$2.0MMolecular Basis of B1-Adrenergic Receptor FunctionR01GM138676 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI HUANG, XIN-YUN · 2020 to 2023
$1.5MMolecular Mechanisms of Apoptosis Regulation Through IP3 ReceptorsF31CA243235 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI PAKNEJAD , NAVID · 2019 to 2022
$179kNCI NIH HHS F31 CA243235NCI NIH HHS P30 CA008748NIGMS NIH HHS P41 GM103310NIGMS NIH HHS R01 GM132307NIGMS NIH HHS R01 GM138676
Abstract
The β
Indexed as
AnimalsCardiac OutputCell LineCryoelectron MicroscopyCyclic AMPEnzyme ActivationGTP-Binding Protein alpha Subunits, Gi-GoGTP-Binding Protein alpha Subunits, GsHeart DiseasesHEK293 CellsHumansHypertensionIsoproterenolProtein Structure, SecondaryProtein Structure, TertiaryReceptors, Adrenergic, beta-1ADRB1 protein, humanCyclic AMPGTP-Binding Protein alpha Subunits, Gi-GoGTP-Binding Protein alpha Subunits, GsIsoproterenolReceptors, Adrenergic, beta-1
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.