ArticleNature2021
Dietary palmitic acid promotes a prometastatic memory via Schwann cells.
Abstract read
In one paragraph
Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 174 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
174citing papers in PubMed, 3 pooled it
18.3field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
174 citing papers in PubMed, 3 syntheses or guidelines pooled it, 297 citations in OpenAlex.
- Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures.Nature communications · 2025Pooled it
- Association of saturated fatty acids with cancer risk: a systematic review and meta-analysis.Lipids in health and disease · 2024Pooled it
- The underexplored links between cancer and the internal body climate: Implications for cancer prevention and treatment.Frontiers in oncology · 2022Pooled it
- Metabolites and cancer metastasis.Oncogene · 2026Review
- Review
- Article
- Diet-Induced Phospholipid Remodeling Dictates Ferroptosis Sensitivity and Tumorigenesis in the Pancreas.Cancer discovery · 2026Article
- Targeting LDHA Palmitoylation Sensitizes GBM to Chemoradiotherapy via Suppressing Palmitic Acid Induced Glycolytic Reprogramming.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Schwann Cell Expression Pattern in Human Melanomas: In Silico and Immunohistochemical Analyses.International journal of molecular sciences · 2026Article
- Inhibition of the lipocalin-2-phosphatidylserine axis restores natural killer cell immune surveillance.Cell reports. Medicine · 2026Article
- Palmitate promotes liver metastases by decreasing neutrophil antitumour behaviour.Nature metabolism · 2026Article
- CEBPG-Mediated Palmitic Acid Adaptation of Cancer-Associated Fibroblasts Drives Metastasis of Oral Squamous Cell Carcinoma.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Tumor-derived stearic acid induces macrophage Egr2 signaling to suppress anti-tumor immunity in breast cancer.bioRxiv : the preprint server for biology · 2026Article
- Dissecting cancer in a non-mammalian model: genomic insights from lemon frost geckos.BMC biology · 2026Article
- Article
- Stromal Regulation of Tumor Perineural Invasion: A Multicellular and Neuro-Ecological Perspective.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- SMAD4 Palmitoylation Drives a Metabolic-Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The lethal symbiont: exploring the pathophysiology of cancer.Physiological reviews · 2026Review
- Fusobacterium periodonticum promotes colorectal tumorigenesis via decanoic acid-driven neutrophil chemotaxis.Nature communications · 2026Article
- Preliminary In Vitro Screening of Structure-Dependent β-Hydroxybutyrate Responses to Dietary Fatty Acids in Hepatocyte Models.Nutrients · 2026Article
114 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
18 authors at 8 institutions in 2 countries.
Gloria Pascual *Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain. Gloria.pascual@irbbarcelona.org.ORCID http://orcid.org/0000-0003-3810-6647
Diana Domínguez *Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.
Marc Elosúa-BayesCNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.ORCID http://orcid.org/0000-0002-3742-8161
Felipe BeckedorffSylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.ORCID http://orcid.org/0000-0001-6735-6851
Carmelo LaudannaInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.ORCID http://orcid.org/0000-0001-8045-320X
Claudia BigasInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.
Delphine DouilletDepartment of Biochemistry and Molecular Genetics and Simpson Querrey Center for Epigenetics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Carolina GrecoCenter for Epigenetics and Metabolism, Department of Biological Chemistry, University of California, Irvine, CA, USA.
Aikaterini SymeonidiInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.
Inmaculada HernándezInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.
Sara Ruiz GilCNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.
Neus PratsInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.
Coro BescósDepartment of Oral and Maxillofacial Surgery, Vall D'Hebron Hospital, Barcelona, Universitat Autònoma de Barcelona, Barcelona, Spain.ORCID http://orcid.org/0000-0002-3865-3037
Ramin ShiekhattarSylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.
Moran AmitDepartment of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Holger HeynCNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.ORCID http://orcid.org/0000-0002-3276-1889
Ali ShilatifardDepartment of Biochemistry and Molecular Genetics and Simpson Querrey Center for Epigenetics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. ASH@northwestern.edu.ORCID http://orcid.org/0000-0002-7490-2854
Salvador Aznar BenitahInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain. Salvador.aznar-benitah@irbbarcelona.org.ORCID http://orcid.org/0000-0002-9059-5049
Institute for Research in Biomedicine · ESCentre for Genomic Regulation · ESNorthwestern University · USUniversity of Miami · USInstitució Catalana de Recerca i Estudis Avançats · ESThe University of Texas MD Anderson Cancer Center · USUniversitat Autònoma de Barcelona · ESUniversity of California, Irvine · US
Funding
Tumor Biology Research ProgramP30CA240139 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Stephen D. Nimer · 2019 to 2026
$24.1MMutations of Chromatin and its Modifying Machineries in MalignanciesR35CA197569 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Ali Shilatifard · 2015 to 2026
$10.7MElucidation of Integrator's FunctionR01GM078455 · NIGMS · WISTAR INSTITUTE · PI SHIEKHATTAR, RAMIN · 2010 to 2025
$5.1MDissecting tumor metabolic heterogeneity in vivoDP2CA228042 · NCI · ROCKEFELLER UNIVERSITY · PI BIRSOY, KIVANC · 2017 to 2017
$2.5MNCI NIH HHS DP2 CA228042NCI NIH HHS P30 CA240139NCI NIH HHS R35 CA197569NIGMS NIH HHS R01 GM078455Worldwide Cancer Research 18-0133
Abstract
Fatty acid uptake and altered metabolism constitute hallmarks of metastasis
Indexed as
Neoplasm MetastasisAnimalsCell Line, TumorChromatinDietary FatsEarly Growth Response Protein 2Extracellular MatrixFemaleGalaninHistonesHumansMaleMicePalmitic AcidSchwann CellsChromatinDietary FatsEarly Growth Response Protein 2EGR2 protein, humanGalaninHistonesPalmitic Acid
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.