Evidence map›Paper›PMID 34759318›Full record

ArticleNature2021

Allometric rules for mammalian cortical layer 5 neuron biophysics.

Lou Beaulieu-Laroche, Norma J Brown, Marissa Hansen, Enrique H S Toloza, Jitendra Sharma, Ziv M Williams, Matthew P Frosch, Garth Rees Cosgrove, Sydney S Cash, Mark T Harnett

Abstract readComparative Study
In one paragraph

Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed.

  1. Article
  2. Dendritic morphology and synaptic nonlinearities enhance functional complexity in human cortical neurons.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Electromechanically induced membrane restructuring enables learning and memory.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lou Beaulieu-LarocheMcGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
Norma J BrownMcGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
Marissa HansenMcGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
Enrique H S TolozaMcGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
Jitendra SharmaPicower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
Ziv M WilliamsDepartment of Neurosurgery, Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-0017-0048
Matthew P FroschC.S. Kubik Laboratory for Neuropathology, Massachusetts General Hospital, Boston, MA, USA.
Garth Rees CosgroveDepartment of Neurosurgery, Brigham and Women's Hospital, Boston, MA, USA.
Sydney S CashDepartment of Neurology, Harvard Medical School and Massachusetts General Hospital, Boston, MA, USA.
Mark T HarnettMcGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA. harnett@mit.edu.ORCID http://orcid.org/0000-0002-5301-1139

Funding

Medical Scientist Training ProgramT32GM007753 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WALENSKY, LOREN DAVID · 1985 to 2021
$50.0M
A dendritic mechanism for cholinergic neuromodulation of cortical functionR01NS106031 · NINDS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI HARNETT, MARK THOMAS · 2018 to 2022
$1.7M
NIGMS NIH HHS T32 GM007753NINDS NIH HHS R01 NS106031
6 · The paper itself

Abstract

The biophysical properties of neurons are the foundation for computation in the brain. Neuronal size is a key determinant of single neuron input-output features and varies substantially across species

Indexed as

BiophysicsCell SizeMammalsAnimalsCerebral CortexDendritesElectric ConductivityHumansHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsMalePotassium Channels, Voltage-GatedPyramidal CellsSpecies SpecificityHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsPotassium Channels, Voltage-Gated

Identifiers

PMID34759318
PMCPMC8665137

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.