ArticleNature2021
Host immunomodulatory lipids created by symbionts from dietary amino acids.
Erratum issuedOpen access · greenAbstract read
In one paragraph
Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 70 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 1 pooled it
7.0field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
70 citing papers in PubMed, 1 synthesis or guideline pooled it, 110 citations in OpenAlex.
- Gut microbiota bridges dietary nutrients and host immunity.Science China. Life sciences · 2023Pooled it
- Bacterial lipid structural diversity mediates commensalism and pathogenesis.Nature reviews. Microbiology · 2026Review
- Metabolic shifts driven by host-microbial interactions.The FEBS journal · 2026Review
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- Beyond α-GalCer: Medicinal Chemistry Insights Driving Structural Evolution of CD1d Ligands.Journal of medicinal chemistry · 2026Review
- Unveiling the Molecular Repertoire ofJournal of microbiology and biotechnology · 2026Review
- Early-life Wnt4 expressing colon stromal cells orchestrate lifelong mucosal homeostasis via BMP-driven iNKT cell imprinting.Nature communications · 2026Article
- Branched-chain fatty acids fire up the peroxisome.Cell research · 2026Article
- Unraveling the mechanisms of PCOS: the interplay between gut microbiota and the immune system.Journal of ovarian research · 2026Review
- Exploring osteosarcopenia from the gut microbiota perspective: mechanistic insights and therapeutic potentials based on the gut-muscle-bone Axis.Frontiers in microbiology · 2026Review
- Synthetic Strategies and Immunological Evaluation of C-Linked α-Galactosylceramide Analogs.Advances in experimental medicine and biology · 2026Review
- The microbiota-NK cell axis in colorectal cancer: a spatial and subset-centric framework.Frontiers in immunology · 2026Review
- Secondary Bile Acids Modified by Odoribacter Splanchnicus Alleviate Colitis by Suppressing Neutrophil Extracellular Trap Formation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Commensal bacterial glycosylation at the interface of host-bacteria interactions.Gut microbes · 2025Review
- Industrial and agricultural chemicals exhibit antimicrobial activity against human gut bacteria in vitro.Nature microbiology · 2025Article
- Novel Role of Gut-Derived Roseburia Intestinalis in Safeguarding Intestinal Barrier Integrity and Microenvironment Homeostasis During Arsenic Exposure.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Human gut bacteria produce structurally related monoglycolipids with contrasting immune functions.Nature microbiology · 2025Article
- Article
- Microbiome-metabolome dynamics associated with impaired glucose control and responses to lifestyle changes.Nature medicine · 2025Article
- Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
15 authors at 5 institutions in 6 countries.
Sungwhan F Oh *Department of Immunology, Blavatnik Institute of Harvard Medical School, Boston, MA, USA. soh2@bwh.harvard.edu.ORCID http://orcid.org/0000-0002-0280-7903
T Praveena *Infection and Immunity Program & Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Heebum SongCRI Center for Chemical Proteomics, Department of Chemistry, Seoul National University, Seoul, Republic of Korea.
Ji-Sun YooCenter for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0003-3100-0794
Da-Jung JungCenter for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Deniz Erturk-HasdemirDepartment of Immunology, Blavatnik Institute of Harvard Medical School, Boston, MA, USA.
Yoon Soo HwangCRI Center for Chemical Proteomics, Department of Chemistry, Seoul National University, Seoul, Republic of Korea.
ChangWon C LeeDepartment of Immunology, Blavatnik Institute of Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-7534-0526
Jérôme Le NoursInfection and Immunity Program & Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Hyunsoo KimCRI Center for Chemical Proteomics, Department of Chemistry, Seoul National University, Seoul, Republic of Korea.
Jesang LeeCRI Center for Chemical Proteomics, Department of Chemistry, Seoul National University, Seoul, Republic of Korea.
Richard S BlumbergDivision of Gastroenterology, Hepatology and Endoscopy, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-9704-248X
Jamie RossjohnInfection and Immunity Program & Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia. jamie.rossjohn@monash.edu.ORCID http://orcid.org/0000-0002-2020-7522
Seung Bum ParkCRI Center for Chemical Proteomics, Department of Chemistry, Seoul National University, Seoul, Republic of Korea. sbpark@snu.ac.kr.ORCID http://orcid.org/0000-0003-1753-1433
Dennis L KasperDepartment of Immunology, Blavatnik Institute of Harvard Medical School, Boston, MA, USA. dennis_kasper@hms.harvard.edu.ORCID http://orcid.org/0000-0001-8808-5333
Seoul National University · KRBrigham and Women's Hospital · USHarvard University · USAustralian Regenerative Medicine Institute · AUAustralian Research Council · AU
Funding
MOLECULAR CHARACTERIZATION OF MUCOSAL LYMPHOCYTESR01DK044319 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI Richard S Blumberg · 1992 to 2026
$10.4MContribution of phytochemicals to gut symbiont colonization and synthesis of immunomodulatory sphingolipidsR01AT010268 · NCCIH · BRIGHAM AND WOMEN'S HOSPITAL · PI OH, SUNGWHAN F · 2019 to 2022
$1.8MNKT Cell Mediated Immunoregulation by Symbiotic Gut Microbial GlycosphingolipidsK01DK102771 · NIDDK · HARVARD MEDICAL SCHOOL · PI OH, SUNGWHAN F · 2015 to 2019
$734kNCCIH NIH HHS R01 AT010268NIDDK NIH HHS K01 DK102771NIDDK NIH HHS R01 DK044319
Abstract
Small molecules derived from symbiotic microbiota critically contribute to intestinal immune maturation and regulation
Indexed as
Amino Acids, Branched-ChainAnimalsAntigens, CD1dBacteroides fragilisGalactosylceramidesGastrointestinal MicrobiomeHumansMiceModels, AnimalModels, MolecularNatural Killer T-CellsReceptors, Antigen, T-CellSignal TransductionSymbiosisAmino Acids, Branched-ChainAntigens, CD1dGalactosylceramidesReceptors, Antigen, T-Cell
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.