Evidence map›Paper›PMID 34759232›Full record

ArticleAsia-Pacific journal of ophthalmology (Philadelphia, Pa.)2021

Assessment and Management of Dry Eye Disease and Meibomian Gland Dysfunction: Providing a Singapore Framework.

Louis Tong, Li Lim, Donald Tan, Wee Jin Heng, Jimmy Lim, Cordelia Chan, Anshu Arundhati, Anna Tan, Corneal Subspecialty Workgroup, College of Ophthalmology, Academy of Medicine, Singapore

Open access · diamondAbstract read
In one paragraph

Article in Asia-Pacific journal of ophthalmology (Philadelphia, Pa.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Article
  4. Review
  5. Review
  6. IL-23 Promotes γδT Cell Activity in Dry Eye Disease Progression.Investigative ophthalmology & visual science · 2025
    Article
  7. Review
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 1 country.

Louis TongCorneal and External Eye Disease Service, Singapore National Eye Centre, Singapore.
Li LimCorneal and External Eye Disease Service, Singapore National Eye Centre, Singapore.
Donald TanYong Loo Lin School of Medicine, Singapore.
Wee Jin HengNational Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore.
Jimmy LimJLEye Specialists, Singapore.
Cordelia ChanDr CordeliaChan@Mt E Novena, Singapore.
Anshu ArundhatiCorneal and External Eye Disease Service, Singapore National Eye Centre, Singapore.
Anna TanDepartment of Ophthalmology, National University Hospital, Singapore.
Corneal Subspecialty Workgroup, College of Ophthalmology, Academy of Medicine, Singapore
Mount Elizabeth Novena Hospital · SGNational University Hospital · SGNational University of Singapore · SGSingapore College of Traditional Chinese Medicine · SGSingapore Eye Research Institute · SGSingapore National Eye Center · SGTan Tock Seng Hospital · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

abstractThe purpose of this article is to provide a framework for general ophthalmologists in Singapore to manage dry eye. This framework considers the evidence in the literature as well as recommendations from expert panels such as the Tear Film & Ocular Surface Society Dry Eye Workshop II and the Asia Cornea Society Workgroup.This article covers the assessment of patient medical history and ask triage questions to identify local and systemic causes of dry eye disease (DED), excluding other possible causes, as well as the risk factors for DED and ocular surface inflammation. Evaluation of clinical signs to establish the diagnosis of DED and differentiation from other causes of irritable, red eyes are described. Tests for understanding the underlying disease processes and severity of DED are also presented.Management of dry eye should involve patient education and engagement. Information about the natural history and chronic nature of DED should be provided to improve long-term management of the disease and enhance compliance. Aggravating factors should be removed or lessened.We provide a guide to determine the most appropriate treatment (or combination of treatments) based on the severity and cause(s) of the disease, as well as the patient's needs and preferences. The aim of the management is to relieve ocular discomfort and prevent worsening of symptoms and signs, as well as to optimize visual function and minimize structural ocular damage. We also discuss the systematic follow-up and assessment of treatment response, as well as monitoring side effects of treatment, bearing in mind continuous support and reassurance to patients.

Indexed as

Dry Eye SyndromesMeibomian Gland DysfunctionCorneaHumansSingaporeTears

Identifiers

PMID34759232
PMCPMC8673856
OpenAlexW3212277537

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.