ArticleDrug metabolism and disposition: the biological fate of chemicals2022
The Lack of Contribution of 7-Hydroxymitragynine to the Antinociceptive Effects of Mitragynine in Mice: A Pharmacokinetic and Pharmacodynamic Study.
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Article in Drug metabolism and disposition: the biological fate of chemicals, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- Atypical respiration patterns of kratom alkaloids.The Journal of pharmacology and experimental therapeutics · 2026Article
- Mixtures Biotransformation: Multilayer Molecular Networking of Kratom Liver Metabolites.Journal of natural products · 2026Article
- Elevated 7-Hydroxymitragynine Levels Found in Products Misbranded as Kratom.Journal of AOAC International · 2026Article
- In Vitro Pharmacology of Mitragynine at α-Adrenoceptors.ACS chemical neuroscience · 2025Article
- Clinically characterizing adults who use kava or kratom: Substance use disorder assessment challenges for increasingly popular botanical products.Drug and alcohol dependence reports · 2025Article
- Mitragynine and 7-hydroxymitragynine: Bidirectional effects on breathing in rats.The Journal of pharmacology and experimental therapeutics · 2025Article
- In Vitro and In Vivo Pharmacokinetic Characterization of 7-Hydroxymitragynine, an Active Metabolite of Mitragynine, in Sprague-Dawley Rats.European journal of drug metabolism and pharmacokinetics · 2025Article
- Controversies in Assessment, Diagnosis, and Treatment of Kratom Use Disorder.Current psychiatry reports · 2024Review
- Multiple-Dose Pharmacokinetics and Safety of Mitragynine, the Major Alkaloid of Kratom, in Rats.ACS pharmacology & translational science · 2024Article
- Effects of kratom on driving: Results from a cross-sectional survey, ecological momentary assessment, and pilot simulated driving Study.Traffic injury prevention · 2024Article
- Kratom as a potential substance use disorder harm reduction agent.Frontiers in public health · 2024Review
- Cannabidiol and mitragynine exhibit differential interactive effects in the attenuation of paclitaxel-induced mechanical allodynia, acute antinociception, and schedule-controlled responding in mice.Pharmacological reports : PR · 2023Article
- Translating Kratom-Drug Interactions: From Bedside to Bench and Back.Drug metabolism and disposition: the biological fate of chemicals · 2023Review
- Pharmacokinetic and Pharmacodynamic Consequences of Cytochrome P450 3A Inhibition on Mitragynine Metabolism in Rats.The Journal of pharmacology and experimental therapeutics · 2023Article
- Kratom alkaloid mitragynine: Inhibition of chemotherapy-induced peripheral neuropathy in mice is dependent on sex and active adrenergic and opioid receptors.IBRO neuroscience reports · 2022Article
- Interactive Effects ofThe Journal of pharmacology and experimental therapeutics · 2022Article
- An update on the clinical pharmacology of kratom: uses, abuse potential, and future considerations.Expert review of clinical pharmacologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 1 institution in 1 country.
Erin C BertholdDepartment of Pharmaceutics, College of Pharmacy, (E.C.B., S.H.K., K.S.R., M.A.K., A.S.S., A.S., C.R.M.), Translational Drug Development Core, Clinical and Translational Science Institute (S.H.K., K.S.R., A.S., C.R.M.), Department of Medicinal Chemistry, College of Pharmacy (M.M., F.L., C.R.M.), and Department of Pharmacodynamics, College of Pharmacy, USA (L.F.R., A.P., N.P.H., T.H., L.R.M.) University of Florida, Gainesville, Florida.ORCID 0000-0003-2868-8073
Shyam H KambleDepartment of Pharmaceutics, College of Pharmacy, (E.C.B., S.H.K., K.S.R., M.A.K., A.S.S., A.S., C.R.M.), Translational Drug Development Core, Clinical and Translational Science Institute (S.H.K., K.S.R., A.S., C.R.M.), Department of Medicinal Chemistry, College of Pharmacy (M.M., F.L., C.R.M.), and Department of Pharmacodynamics, College of Pharmacy, USA (L.F.R., A.P., N.P.H., T.H., L.R.M.) University of Florida, Gainesville, Florida.ORCID 0000-0002-1664-1692
Kanumuri S RajuDepartment of Pharmaceutics, College of Pharmacy, (E.C.B., S.H.K., K.S.R., M.A.K., A.S.S., A.S., C.R.M.), Translational Drug Development Core, Clinical and Translational Science Institute (S.H.K., K.S.R., A.S., C.R.M.), Department of Medicinal Chemistry, College of Pharmacy (M.M., F.L., C.R.M.), and Department of Pharmacodynamics, College of Pharmacy, USA (L.F.R., A.P., N.P.H., T.H., L.R.M.) University of Florida, Gainesville, Florida.
Michelle A KuntzDepartment of Pharmaceutics, College of Pharmacy, (E.C.B., S.H.K., K.S.R., M.A.K., A.S.S., A.S., C.R.M.), Translational Drug Development Core, Clinical and Translational Science Institute (S.H.K., K.S.R., A.S., C.R.M.), Department of Medicinal Chemistry, College of Pharmacy (M.M., F.L., C.R.M.), and Department of Pharmacodynamics, College of Pharmacy, USA (L.F.R., A.P., N.P.H., T.H., L.R.M.) University of Florida, Gainesville, Florida.
Alexandria S SenetraDepartment of Pharmaceutics, College of Pharmacy, (E.C.B., S.H.K., K.S.R., M.A.K., A.S.S., A.S., C.R.M.), Translational Drug Development Core, Clinical and Translational Science Institute (S.H.K., K.S.R., A.S., C.R.M.), Department of Medicinal Chemistry, College of Pharmacy (M.M., F.L., C.R.M.), and Department of Pharmacodynamics, College of Pharmacy, USA (L.F.R., A.P., N.P.H., T.H., L.R.M.) University of Florida, Gainesville, Florida.
Marco MottinelliDepartment of Pharmaceutics, College of Pharmacy, (E.C.B., S.H.K., K.S.R., M.A.K., A.S.S., A.S., C.R.M.), Translational Drug Development Core, Clinical and Translational Science Institute (S.H.K., K.S.R., A.S., C.R.M.), Department of Medicinal Chemistry, College of Pharmacy (M.M., F.L., C.R.M.), and Department of Pharmacodynamics, College of Pharmacy, USA (L.F.R., A.P., N.P.H., T.H., L.R.M.) University of Florida, Gainesville, Florida.
Francisco LeónDepartment of Pharmaceutics, College of Pharmacy, (E.C.B., S.H.K., K.S.R., M.A.K., A.S.S., A.S., C.R.M.), Translational Drug Development Core, Clinical and Translational Science Institute (S.H.K., K.S.R., A.S., C.R.M.), Department of Medicinal Chemistry, College of Pharmacy (M.M., F.L., C.R.M.), and Department of Pharmacodynamics, College of Pharmacy, USA (L.F.R., A.P., N.P.H., T.H., L.R.M.) University of Florida, Gainesville, Florida.ORCID 0000-0002-5064-2381
Luis F RestrepoDepartment of Pharmaceutics, College of Pharmacy, (E.C.B., S.H.K., K.S.R., M.A.K., A.S.S., A.S., C.R.M.), Translational Drug Development Core, Clinical and Translational Science Institute (S.H.K., K.S.R., A.S., C.R.M.), Department of Medicinal Chemistry, College of Pharmacy (M.M., F.L., C.R.M.), and Department of Pharmacodynamics, College of Pharmacy, USA (L.F.R., A.P., N.P.H., T.H., L.R.M.) University of Florida, Gainesville, Florida.
Avi PatelDepartment of Pharmaceutics, College of Pharmacy, (E.C.B., S.H.K., K.S.R., M.A.K., A.S.S., A.S., C.R.M.), Translational Drug Development Core, Clinical and Translational Science Institute (S.H.K., K.S.R., A.S., C.R.M.), Department of Medicinal Chemistry, College of Pharmacy (M.M., F.L., C.R.M.), and Department of Pharmacodynamics, College of Pharmacy, USA (L.F.R., A.P., N.P.H., T.H., L.R.M.) University of Florida, Gainesville, Florida.
Nicholas P HoDepartment of Pharmaceutics, College of Pharmacy, (E.C.B., S.H.K., K.S.R., M.A.K., A.S.S., A.S., C.R.M.), Translational Drug Development Core, Clinical and Translational Science Institute (S.H.K., K.S.R., A.S., C.R.M.), Department of Medicinal Chemistry, College of Pharmacy (M.M., F.L., C.R.M.), and Department of Pharmacodynamics, College of Pharmacy, USA (L.F.R., A.P., N.P.H., T.H., L.R.M.) University of Florida, Gainesville, Florida.
Takato HiranitaDepartment of Pharmaceutics, College of Pharmacy, (E.C.B., S.H.K., K.S.R., M.A.K., A.S.S., A.S., C.R.M.), Translational Drug Development Core, Clinical and Translational Science Institute (S.H.K., K.S.R., A.S., C.R.M.), Department of Medicinal Chemistry, College of Pharmacy (M.M., F.L., C.R.M.), and Department of Pharmacodynamics, College of Pharmacy, USA (L.F.R., A.P., N.P.H., T.H., L.R.M.) University of Florida, Gainesville, Florida.
Abhisheak SharmaDepartment of Pharmaceutics, College of Pharmacy, (E.C.B., S.H.K., K.S.R., M.A.K., A.S.S., A.S., C.R.M.), Translational Drug Development Core, Clinical and Translational Science Institute (S.H.K., K.S.R., A.S., C.R.M.), Department of Medicinal Chemistry, College of Pharmacy (M.M., F.L., C.R.M.), and Department of Pharmacodynamics, College of Pharmacy, USA (L.F.R., A.P., N.P.H., T.H., L.R.M.) University of Florida, Gainesville, Florida.ORCID 0000-0003-0553-4039
Lance R McMahonDepartment of Pharmaceutics, College of Pharmacy, (E.C.B., S.H.K., K.S.R., M.A.K., A.S.S., A.S., C.R.M.), Translational Drug Development Core, Clinical and Translational Science Institute (S.H.K., K.S.R., A.S., C.R.M.), Department of Medicinal Chemistry, College of Pharmacy (M.M., F.L., C.R.M.), and Department of Pharmacodynamics, College of Pharmacy, USA (L.F.R., A.P., N.P.H., T.H., L.R.M.) University of Florida, Gainesville, Florida.
Christopher R McCurdyDepartment of Pharmaceutics, College of Pharmacy, (E.C.B., S.H.K., K.S.R., M.A.K., A.S.S., A.S., C.R.M.), Translational Drug Development Core, Clinical and Translational Science Institute (S.H.K., K.S.R., A.S., C.R.M.), Department of Medicinal Chemistry, College of Pharmacy (M.M., F.L., C.R.M.), and Department of Pharmacodynamics, College of Pharmacy, USA (L.F.R., A.P., N.P.H., T.H., L.R.M.) University of Florida, Gainesville, Florida cmccurdy@cop.ufl.edu asharma1@cop.ufl.edu.
University of Florida · US
Funding
Using social networks to map and evaluate team science across CTSA hubsUL1TR001427 · NCATS · UNIVERSITY OF FLORIDA · PI MITCHELL, DUANE A. · 2015 to 2024
$37.2MOpioid use disorders: UF Pharmacy medications discovery and developmentUH3DA048353 · NIDA · UNIVERSITY OF FLORIDA · PI MCCURDY, CHRISTOPHER R, MCMAHON, LANCE R. · 2021 to 2023
$4.5MOpioid use disorders: UF Pharmacy medications discovery and developmentUG3DA048353 · NIDA · UNIVERSITY OF FLORIDA · PI MCCURDY, CHRISTOPHER R, MCMAHON, LANCE R. · 2019 to 2020
$3.6MKratom alkaloids: in vitro and in vivo pharmacological mechanismsR01DA047855 · NIDA · UNIVERSITY OF FLORIDA · PI MCCURDY, CHRISTOPHER R, MCMAHON, LANCE R. · 2019 to 2023
$3.6MNCATS NIH HHS UL1 TR001427NIDA NIH HHS R01 DA047855NIDA NIH HHS UG3 DA048353NIDA NIH HHS UH3 DA048353
Abstract
Kratom (
Indexed as
Secologanin Tryptamine AlkaloidsAnalgesics, OpioidAnimalsFemaleMaleMiceMice, Inbred C57BL7-hydroxymitragynineAnalgesics, OpioidmitragynineSecologanin Tryptamine Alkaloids
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.