Evidence map›Paper›PMID 34758879›Full record

ReviewHereditas2021

The role of ceRNA-mediated diagnosis and therapy in hepatocellular carcinoma.

Yi Shi, Ji-Bin Liu, Jing Deng, Da-Zhi Zou, Jian-Jun Wu, Ya-Hong Cao, Jie Yin, Yu-Shui Ma, Fu Da, Wen Li

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Hereditas, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
4.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 59 citations in OpenAlex.

  1. Article
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  13. Exploring the Key Signaling Pathways and ncRNAs in Colorectal Cancer.International journal of molecular sciences · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Yi Shi *College of Life Sciences and Chemistry, Hunan University of Technology, Zhuzhou, 412007, Hunan, China.
Ji-Bin Liu *Cancer Institute, Affiliated Tumor Hospital of Nantong University, Nantong, 226631, China.
Jing Deng *National Engineering Laboratory for Deep Process of Rice and Byproducts, College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha, 410004, Hunan, China.
Da-Zhi ZouDepartment of Spine Surgery, Longhui County People's Hospital, Longhui, 422200, Hunan, China.
Jian-Jun WuNantong Haimen Yuelai Health Centre, Haimen, 226100, China.
Ya-Hong CaoDepartment of Respiratory, Nantong Traditional Chinese Medicine Hospital, Nantong, 226019, Jiangsu Province, China.
Jie YinDepartment of General Surgery, Haian people's Hospital, Haian, 226600, Jiangsu, China.
Yu-Shui MaCancer Institute, Affiliated Tumor Hospital of Nantong University, Nantong, 226631, China. mayushui@tongji.edu.cn.
Fu DaCancer Institute, Affiliated Tumor Hospital of Nantong University, Nantong, 226631, China. fu800da900@126.com.ORCID http://orcid.org/0000-0002-0878-2575
Wen LiCollege of Life Sciences and Chemistry, Hunan University of Technology, Zhuzhou, 412007, Hunan, China. liwendream@163.com.
Central South University of Forestry and Technology · CNNantong University · CN

Funding

National Natural Science Foundation of China 81772932, 81972214, 81472202 and 81302065
6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide due to its high degree of malignancy, high incidence, and low survival rate. However, the underlying mechanisms of hepatocarcinogenesis remain unclear. Long non coding RNA (lncRNA) has been shown as a novel type of RNA. lncRNA by acting as ceRNA can participate in various biological processes of HCC cells, such as tumor cell proliferation, migration, invasion, apoptosis and drug resistance by regulating downstream target gene expression and cancer-related signaling pathways. Meanwhile, lncRNA can predict the efficacy of treatment strategies for HCC and serve as a potential target for the diagnosis and treatment of HCC. Therefore, lncRNA serving as ceRNA may become a vital candidate biomarker for clinical diagnosis and treatment. In this review, the epidemiology of HCC, including morbidity, mortality, regional distribution, risk factors, and current treatment advances, was briefly discussed, and some biological functions of lncRNA in HCC were summarized with emphasis on the molecular mechanism and clinical application of lncRNA-mediated ceRNA regulatory network in HCC. This paper can contribute to the better understanding of the mechanism of the influence of lncRNA-mediated ceRNA networks (ceRNETs) on HCC and provide directions and strategies for future studies.

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsMicroRNAsGene Expression Regulation, NeoplasticHumansPrognosisMicroRNAsceRNAceRNETEpidemiologyFunctionHCCMechanism

Identifiers

PMID34758879
PMCPMC8582193
OpenAlexW3212461106

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.