ArticleDiabetology & metabolic syndrome2021
The association between fat-to-muscle ratio and metabolic disorders in type 2 diabetes.
Article in Diabetology & metabolic syndrome, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 31 citations in OpenAlex.
- Article
- Visceral Adiposity, Rather than Reduced Appendicular Lean Mass, Characterizes Elderly Hip Fracture Patients with Type 2 Diabetes: A Cross-Sectional DXA Analysis.Journal of clinical medicine · 2026Article
- Muscle quality index and phase angle responses to matched-volume resistance training at different frequencies in older women.Physical activity and nutrition · 2026Article
- Fractal Analysis of Intramuscular Adipose Tissue on CT Serves as a Novel Imaging Biomarker for Metabolic Syndrome.International journal of medical sciences · 2026Article
- Low initial body fat percentage exacerbates skeletal muscle loss and increases the risk of hyperuricemia during high-altitude acclimatization in young men.Frontiers in nutrition · 2026Article
- Comparison of Abdominal Muscle and Subcutaneous Fat Thickness and Core Stability between Normal Weight Non-Obesity, Normal Weight Obesity, and Obesity Groups in Young Korean Women.Iranian journal of public health · 2025Article
- Body Muscle-to-Fat Ratio (BMFR) as a Promising Anthropometric Index for Use in the Evaluation of Insulin Resistance and Metabolic Disease Risk: a Narrative Review.Current obesity reports · 2025Review
- Peripheral Thyroid Hormone Sensitivity Mediates the Association Between Body Composition and Diabetes in Euthyroid Adults.Journal of cachexia, sarcopenia and muscle · 2025Article
- Association between morphological and mechanical properties of lower limb muscles and metabolic syndrome in type 2 diabetes.Diabetology & metabolic syndrome · 2025Article
- Association of fat-to-muscle ratio with hypertension: a cross-sectional study in China.Journal of human hypertension · 2025Article
- Relationship Between Fat-to-Muscle Ratio and Nonalcoholic Fatty Liver Disease in Middle-Aged and Older Adults with Type 2 Diabetes: Cross-Sectional Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Assessment of body compositions in the prediction of metabolic syndrome in adults.Quantitative imaging in medicine and surgery · 2024Article
- The longitudinal association of adipose-to-lean ratio with incident cardiometabolic morbidity: The CARDIA study.Journal of diabetes and its complications · 2024Article
- Diet and Lifestyle Intervention-Induced Pattern of Weight Loss Related to Reduction in Low-Attenuation Coronary Plaque Burden.Diagnostics (Basel, Switzerland) · 2024Article
- Article
- Low muscle mass index is associated with type 2 diabetes risk in a Latin-American population: a cross-sectional study.Frontiers in nutrition · 2024Article
- Normal-Weight Obesity and Metabolic Syndrome in Korean Adults: A Population-Based Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2023Article
- Age-specific and sex-specific associations of visceral adipose tissue mass and fat-to-muscle mass ratio with risk of mortality.Journal of cachexia, sarcopenia and muscle · 2023Article
- Combining Fat-to-Muscle Ratio and Alanine Aminotransferase/Aspartate Aminotransferase Ratio in the Prediction of Cardiometabolic Risk: A Cross-Sectional Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Article
- Elevated Chinese visceral adiposity index increases the risk of stroke in Chinese patients with metabolic syndrome.Frontiers in endocrinology · 2023Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAltered body composition is known to be related to abnormal metabolism. The aim of this study was to determine the association between the fat-to-muscle ratio (FMR) and metabolic disorders in type 2 diabetes (T2DM) population.
methodIn total, 361 T2DM participants aged ≥ 18 years were included in our research. A bioelectrical impedance analyzer was applied to measure fat mass and muscle mass. FMR was calculated as body fat mass (kg) divided by muscle mass (kg). The performance of FMR to assess metabolic disorders in T2DM was conducted using ROC curves. The independent association between FMR and metabolic syndrome (MS) was tested by logistic regression analysis.
resultsThe FMR was significantly higher in patients with MS than in those without MS (p < 0.001). The optimal FMR cutoff point for identifying MS was higher in females than in males (0.465 vs. 0.296, respectively). In addition, the areas under the ROC curve (AUCs) for the evaluation of MS by FMR, fat mass, muscle mass, BMI and waist circumference were further compared, indicating that the AUC of FMR (0.843) was the largest among the five variables in females, but the AUC of waist circumference (0.837) was still the largest among other variables in males. Based on the derived FMR cutoff point, patients with a high FMR exhibited more cardiometabolic risk indicators (all p < 0.05). Using a low FMR as a reference, the relative risk of a high FMR for MS was 2.861 (95% CI 1.111-7.368, p = 0.029) in males and 9.518 (95% CI 2.615-34.638, p = 0.001) in females following adjustment for confounding factors.
conclusionsThe fat-to-muscle ratio is independently and positively associated with metabolic disorders in T2DM. FMR may serve as an optimal method for screening T2DM patients coupled with a high risk of abnormal metabolism, especially in females, providing a new perspective for the prevention and treatment of cardiovascular complications in Chinese type 2 diabetes.
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