Evidence map›Paper›PMID 34758857›Full record

ArticleJournal of neuroengineering and rehabilitation2021

Usability and performance validation of an ultra-lightweight and versatile untethered robotic ankle exoskeleton.

Greg Orekhov, Ying Fang, Chance F Cuddeback, Zachary F Lerner

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Journal of neuroengineering and rehabilitation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04119063 (Evaluating Wearable Robotic Assistance on Gait Mechanics and Energetics in Individuals With Neurological Impairment), which is not on this map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04119063 early_phase1completednot on this map

Evaluating Wearable Robotic Assistance on Gait Mechanics and Energetics in Individuals With Neurological Impairment

TypeinterventionalSponsorNorthern Arizona UniversityRan2019 to 2022Enrolled6ConditionsCerebral PalsyArmspowered orthosis
3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Ankle Exoskeleton Assistance Reduces Knee Contact Force During Walking in Individuals With Cerebral Palsy.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2026
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  6. Review
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  8. Methodology for the knowledge-based selection of occupational exoskeletons.Production engineering : research and development · 2025
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  12. Walking on Real-world Terrain with an Ankle Exoskeleton in Cerebral Palsy.IEEE transactions on medical robotics and bionics · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Greg OrekhovDepartment of Mechanical Engineering, Northern Arizona University, 15600 S McConnell Drive, NAU EGR Bldg 69, Flagstaff, AZ, 86011, USA.
Ying FangDepartment of Mechanical Engineering, Northern Arizona University, 15600 S McConnell Drive, NAU EGR Bldg 69, Flagstaff, AZ, 86011, USA.
Chance F CuddebackDepartment of Mechanical Engineering, Northern Arizona University, 15600 S McConnell Drive, NAU EGR Bldg 69, Flagstaff, AZ, 86011, USA.
Zachary F LernerDepartment of Mechanical Engineering, Northern Arizona University, 15600 S McConnell Drive, NAU EGR Bldg 69, Flagstaff, AZ, 86011, USA. Zachary.Lerner@nau.edu.ORCID 0000-0002-7359-436X
Northern Arizona University · USUniversity of Arizona · US

Funding

Development of a robotic ankle assist device to improve mobility in individuals with movement disorders.R44HD104328 · NICHD · BIOMOTUM, LLC · PI BROWNING, RAYMOND CLIFTON · 2020 to 2022
$2.0M
Wearable Ankle Assistance to Improve Walking Economy in Children with Cerebral PalsyR15HD099664 · NICHD · NORTHERN ARIZONA UNIVERSITY · PI LERNER, ZACHARY FOREST · 2019 to 2019
$424k
NICHD NIH HHS R15 HD099664NICHD NIH HHS R44 HD104328
6 · The paper itself

Abstract

backgroundAnkle exoskeletons can improve walking mechanics and energetics, but few untethered devices have demonstrated improved performance and usability across a wide range of users and terrains. Our goal was to design and validate a lightweight untethered ankle exoskeleton that was effective across moderate-to-high intensity ambulation in children through adults with and without walking impairment.

methodsFollowing benchtop validation of custom hardware, we assessed the group-level improvements in walking economy while wearing the device in a diverse unimpaired cohort (n = 6, body mass = 42-92 kg). We also conducted a maximal exertion experiment on a stair stepping machine in a small cohort of individuals with cerebral palsy (CP, n = 5, age = 11-33 years, GMFCS I-III, body mass = 40-71 kg). Device usability metrics (device don and setup times and System Usability Score) were assessed in both cohorts.

resultsThere was a 9.9 ± 2.6% (p = 0.012, range = 0-18%) reduction in metabolic power during exoskeleton-assisted inclined walking compared to no device in the unimpaired cohort. The cohort with CP was able to ascend 38.4 ± 23.6% (p = 0.013, range = 3-132%) more floors compared to no device without increasing metabolic power (p = 0.49) or perceived exertion (p = 0.50). Users with CP had mean device don and setup times of 3.5 ± 0.7 min and 28 ± 6 s, respectively. Unimpaired users had a mean don time of 1.5 ± 0.2 min and setup time of 14 ± 1 s. The average exoskeleton score on the System Usability Scale was 81.8 ± 8.4 ("excellent").

conclusionsOur battery-powered ankle exoskeleton was easy to use for our participants, with initial evidence supporting effectiveness across different terrains for unimpaired adults, and children and adults with CP. Trial registration Prospectively registered at ClinicalTrials.gov (NCT04119063) on October 8, 2019.

Indexed as

Exoskeleton DeviceRobotic Surgical ProceduresAdolescentAdultAnkleAnkle JointBiomechanical PhenomenaChildHumansWalkingYoung AdultAnkleCerebral palsyDorsiflexor assistanceExoskeletonIncline walkingMetabolic powerPlantarflexor assistanceStair ascent

Identifiers

PMID34758857
PMCPMC8579560
OpenAlexW3211834041

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.