Evidence map›Paper›PMID 34758845›Full record

ArticleMolecular brain2021

VMAT2 availability in Parkinson's disease with probable REM sleep behaviour disorder.

Mikaeel Valli, Sang Soo Cho, Carme Uribe, Mario Masellis, Robert Chen, Alexander Mihaescu, Antonio P Strafella

Open access · goldAbstract read
In one paragraph

Article in Molecular brain, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.6field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Review
  3. Multitype hand writing as a digital marker for Parkinson's disease.Clinical parkinsonism & related disorders · 2026
    Article
  4. Increased frontal [NPJ Parkinson's disease · 2025
    Article
  5. Tricyclic and tetracyclic antidepressants upregulate VMAT2 activity and rescue disease-causing VMAT2 variants.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Mikaeel ValliBrain Health Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada. mikaeel.valli@mail.utoronto.ca.ORCID 0000-0002-4059-2333
Sang Soo ChoDepartment of Brain and Cognitive Science, Seoul National University, Seoul, Republic of Korea.
Carme UribeBrain Health Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada.
Mario MasellisInstitute of Medical Science, University of Toronto, Toronto, ON, Canada.
Robert ChenDivision of Brain, Imaging and Behaviour - Systems Neuroscience, Krembil Brain Institute, UHN, University of Toronto, Toronto, ON, Canada.
Alexander MihaescuBrain Health Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada.
Antonio P StrafellaBrain Health Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada. antonio.strafella@uhn.ca.
Centre for Addiction and Mental Health · CASeoul National University · KRSunnybrook Health Science Centre · CAUniversity of Toronto · CA

Funding

CIHR MOP 136778
6 · The paper itself

Abstract

REM sleep behaviour disorder (RBD) can be an early non-motor symptom of Parkinson's disease (PD) with pathology involving mainly the pontine nuclei. Beyond the brainstem, it is unclear if RBD patients comorbid with PD have more affected striatal dopamine denervation compared to PD patients unaffected by RBD (PD-RBD-). To elucidate this, we evaluated the availability of vesicular monoamine transporter 2 (VMAT2), an index of nigrostriatal dopamine innervation, in 15 PD patients with probable RBD (PD-RBD+), 15 PD-RBD-, and 15 age-matched healthy controls (HC) using [

Indexed as

Parkinson DiseaseREM Sleep Behavior DisorderCorpus StriatumDopamine Plasma Membrane Transport ProteinsHumansVesicular Monoamine Transport ProteinsDopamine Plasma Membrane Transport ProteinsSLC18A2 protein, humanVesicular Monoamine Transport Proteins[11C]DTBZParkinson’s diseasePositron emission tomographyREM sleep behaviour disorderVMAT2

Identifiers

PMID34758845
PMCPMC8579554
OpenAlexW3212062980

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.