ArticleJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance2021
Impaired left atrial reservoir and conduit strain in patients with atrial fibrillation and extensive left atrial fibrosis.
Article in Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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43 citing papers in PubMed, 66 citations in OpenAlex.
- Left Atrial Function Predicts Atrial Arrhythmia Recurrence Following Ablation of Long-Standing Persistent Atrial Fibrillation.Circulation. Cardiovascular imaging · 2023Trial
- Atrial and ventricular mechanical dysfunction and myocardial injury predict long-term outcomes in hypertrophic cardiomyopathy: a retrospective cohort study.Quantitative imaging in medicine and surgery · 2026Article
- Automated Echocardiographic Assessment of Left Atrial Remodeling in Atrial Fibrillation Using Dynamic HeartModel and AutoStrain LA.Echocardiography (Mount Kisco, N.Y.) · 2026Article
- Echocardiographic strain imaging and progression of atrial fibrillation in low-risk individuals.International journal of cardiology. Heart & vasculature · 2026Article
- Association of left atrial volume and function parameters with cardiovascular outcomes following kidney transplantation.Cardiovascular ultrasound · 2026Article
- Comparative cardiac electrophysiological analysis between sinus rhythm and atrial fibrillation: The correlation of left atrial low-voltage substrate of sex and rhythm.Heart rhythm O2 · 2026Article
- Systematic computational assessment of atrial function impairment due to fibrotic remodeling in electromechanical properties.PLoS computational biology · 2025Article
- Echocardiographic assessment of peak atrial longitudinal strain in paroxysmal atrial fibrillation patients compared to age-matched controls.Clinical physiology and functional imaging · 2025Article
- Comprehensive Assessment of Left Atrial Function: The Emerging Role of Cardiac Magnetic Resonance Feature Tracking.Journal of cardiovascular development and disease · 2025Review
- Is regional atrial strain a useful surrogate of regional atrial fibrosis in atrial cardiomyopathy?European heart journal. Imaging methods and practice · 2025Article
- 2025 THRS Expert Consensus of Imaging Assessment in Atrial Fibrillation.Acta Cardiologica Sinica · 2025Article
- Left atrial function and fibrosis in lifelong endurance athletes: a cardiac magnetic resonance imaging study.The international journal of cardiovascular imaging · 2025Article
- Time's imprint on the left atrium: aging and atrial myopathy.The journal of cardiovascular aging · 2025Article
- Echocardiographic Predictors of Postoperative Atrial Fibrillation After Cardiac Surgery: Assessing Atrial Mechanics for Risk Stratification.Journal of cardiovascular development and disease · 2025Article
- Left Atrial Myocardial Mechanics: Association With Cognitive Dysfunction, Cerebrovascular Disease, and Circulating Biomarkers.Journal of the American Heart Association · 2025Article
- Evaluating pulmonary stenosis and regurgitation impact on cardiac strain and strain rate in a porcine model via magnetic resonance feature tracking.The international journal of cardiovascular imaging · 2025Article
- Right atrial strain in atrial fibrillation: the hidden side of the moon.Frontiers in cardiovascular medicine · 2025Article
- Impact of comorbid burden on global left cardiac function and prediction models for myocardial function damage: a cardiac magnetic resonance feature-tracking study.Frontiers in medicine · 2025Article
- Multiphysics simulations reveal haemodynamic impacts of patient-derived fibrosis-related changes in left atrial tissue mechanics.The Journal of physiology · 2024Article
- Cardiac Functional Assessment by Magnetic Resonance Imaging.Cardiology discovery · 2024Review
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Authors and funding
8 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundAtrial fibrillation (AF) is associated with profound structural and functional changes in the atria. In the present study, we investigated the association between left atrial (LA) phasic function and the extent of LA fibrosis using advanced cardiovascular magnetic resonance (CMR) imaging techniques, including 3-dimensional (3D) late gadolinium enhancement (LGE) and feature tracking.
methodsPatients with paroxysmal and persistent AF (n = 105) underwent CMR in sinus rhythm. LA global reservoir strain, conduit strain and contractile strain were derived from cine CMR images using CMR feature tracking. The extent of LA fibrosis was assessed from 3D LGE images. Healthy subjects underwent CMR and served as controls (n = 19).
resultsSignificantly lower LA reservoir strain, conduit strain and contractile strain were found in AF patients, as compared to healthy controls (- 15.9 ± 3.8% vs. - 21.1 ± 3.6% P < 0.001, - 8.7 ± 2.7% vs. - 12.6 ± 2.5% P < 0.001 and - 7.2 ± 2.3% vs. - 8.6 ± 2.2% P = 0.02, respectively). Patients with a high degree of LA fibrosis (dichotomized by the median value) had lower reservoir strain and conduit strain compared to patients with a low degree of LA fibrosis (- 15.0 ± 3.9% vs. - 16.9 ± 3.3%, P = 0.02 and - 7.9 ± 2.7% vs. - 9.5 ± 2.6%, P = 0.01, respectively). In contrast, no difference was found for LA contractile strain (- 7.1 ± 2.4% vs. - 7.4 ± 2.3%, P = 0.55).
conclusionsImpaired LA reservoir and conduit strain are present in AF patients with extensive atrial fibrosis. Future studies are needed to examine the biologic nature of this association and possible therapeutic implications.
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