ArticleThe Journal of international medical research2021
Prognostic factors of patients with advanced lung cancer treated with anlotinib: a retrospective cohort study.
Article in The Journal of international medical research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveOur study aimed to evaluate the main factors affecting the efficacy of anlotinib to determine the therapeutically dominant populations.
methodsThe medical records of patients with lung cancer who were treated with anlotinib from July 2018 to February 2020 at Renji Hospital, School of Medicine, Shanghai Jiaotong University were retrospectively reviewed. The optimal cutoff prognostic nutritional index (PNI) value for predicting efficacy was determined according to receiver operating characteristic curves. Progression-free survival (PFS) and overall survival (OS) were calculated and compared using the Kaplan-Meier method and log-rank test. The prognostic values of each variable were evaluated with univariate and multivariate Cox proportional hazard regression analyses.
resultsThe overall disease control rate of 44 patients with lung cancer was 93.2% (41/44). The median PFS was 5.0 months (95% [confidence interval] CI: 2.2-7.8), and the median OS was 6.5 months (95% CI: 3.6-9.3). The multivariate analysis results indicated that hand-foot syndrome and high PNI values were independent protective factors of PFS and OS.
conclusionsAnlotinib was effective in treating locally advanced or advanced lung cancer. High pretreatment PNI scores and the presence of hand-foot syndrome after treatment were independent prognostic markers for favorable OS and PFS.
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