Evidence map›Paper›PMID 34758666›Full record

ArticleExperimental biology and medicine (Maywood, N.J.)2022

The alleles of AGT and HIF1A gene affect the risk of hypertension in plateau residents.

Zongjin Li, Xi Hu, Jinping Wan, Jiyu Yang, Zeyu Jia, Liqin Tian, Xiaoming Wu, Changxin Song, Chengying Yan

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental biology and medicine (Maywood, N.J.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Zongjin LiDepartment of Computer, Qinghai Normal University, Xining, Qinghai 810000, China.ORCID 0000-0003-2134-2651
Xi HuThe Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, Shaanxi 710049, China.
Jinping WanThe Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, Shaanxi 710049, China.
Jiyu YangDepartment of Cardiovascular Medicine, Xining First People's Hospital, Xining 810000, China.
Zeyu JiaDepartment of Computer, Qinghai Normal University, Xining, Qinghai 810000, China.
Liqin TianDepartment of Computer, Qinghai Normal University, Xining, Qinghai 810000, China.
Xiaoming WuThe Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, Shaanxi 710049, China.
Changxin SongDepartment of Mechanical engineering and information, Shanghai Urban Construction Vocational College, Shanghai 200000, China.
Chengying YanDepartment of Cardiovascular Medicine, Xining First People's Hospital, Xining 810000, China.
Xi'an Jiaotong University · CNQinghai Normal University · CNNorth China Institute of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Plateau essential hypertension is a common chronic harmful disease of permanent residents in plateau areas. Studies have shown some single nucleotide polymorphisms (SNPs) associations with hypertension, but few have been verified in plateau area-lived people. In this paper, we examined some hypertension-related gene loci to analyze the relationship between risk SNPs and plateau essential hypertension in residents in Qinghai-Tibet plateau area. We screened hypertension-related SNPs from the literature, Clinvar database, GHR database, GTR database, and GWAS database, and then selected 101 susceptible SNPs for detection. Illumina MiSeq NGS platform was used to perform DNA sequencing on the blood samples from 185 Tibetan dwellings of Qinghai, and bioinformatic tools were used to make genotyping. Genetic models adjusted by gender and age were used to calculate the risk effects of genotypes. Four known SNPs as well as a new locus were found associated with PHE, which were rs2493134 (AGT), rs9349379 (PHACTR1), rs1371182 (CYP2C56P-PRPS1P1), rs567481079 (CYP2C56P-PRPS1P1), and chr14:61734822 (HIF1A). Among them, genotypes of rs2493134, rs9349379, and rs567481079 were risk factors, genotypes of rs1371182 and chr14:61734822 were protective factors. The rs2493134 in AGT was found associated with an increased risk of the plateau essential hypertension by 3.24-, 3.24-, and 2.06-fold in co-dominant, dominant, and Log-additive models, respectively. The rs9349379 in PHACTR1 is associated with a 2.61-fold increased risk of plateau essential hypertension according to the dominant model. This study reveals that the alleles of AGT, HIF1A, and PHACTR1 are closely related to plateau essential hypertension risk in the plateau Tibetan population.

Indexed as

Polymorphism, Single NucleotideAgedAllelesAltitudeAngiotensinogenCase-Control StudiesEssential HypertensionFemaleGenetic Predisposition to DiseaseHumansHypoxia-Inducible Factor 1, alpha SubunitMaleMiddle AgedModels, GeneticTibetAGT protein, humanAngiotensinogenHIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitAGTassociation analysisHIF1APlateau essential hypertensionQinghai Tibetan populationsingle nucleotide polymorphisms (SNPs)

Identifiers

PMID34758666
PMCPMC8851529
OpenAlexW3214219328

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.