ArticleAngewandte Chemie (International ed. in English)2022
Control over Multiple Nano- and Secondary Structures in Peptide Self-Assembly.
Article in Angewandte Chemie (International ed. in English), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Advances in Dynamic/Adaptive Supramolecular Self-Assembly: From Molecular Design to Stimuli-Responsive Control.Macromolecular rapid communications · 2026Pooled it
- Induction and Stabilization of Peptide Alpha-Helices on Silica Nanoparticles.Angewandte Chemie (International ed. in English) · 2026Article
- Cosolvent-Modulated Supramolecular Chirality Unveils Pronounced Piezoelectric Response in Peptide-Based Nanomaterials.Angewandte Chemie (International ed. in English) · 2026Article
- Injectable dual-affinity self-assembling peptide hydrogels for local controlled delivery of therapeutic antibodies.Asian journal of pharmaceutical sciences · 2026Article
- Mechanically Enhanced Ultrashort Peptide Hydrogels for pH-Triggered Release.ACS polymers Au · 2026Article
- Self-Assembling Short Peptide Carriers for Gene Delivery.International journal of molecular sciences · 2026Review
- Intrinsically Fluorescent Nano-Scaled Peptide Aggregates Upon Arginine to Citrulline Swap.Biotechnology and bioengineering · 2026Article
- Chiroptical switching and strong circularly polarized luminescence in peptide supramolecular assemblies.Nature communications · 2025Article
- Antioxidant Peptide-Based Nanocarriers for Delivering Wound Healing Agents.Tissue engineering and regenerative medicine · 2025Article
- Harnessing Amino Acid Modularity for Programmable Function in Covalent Peptide Assemblies.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Synthetic chitin oligosaccharide nanocrystals and their higher-order assemblies.Chemical science · 2025Article
- Molecular and supramolecular adaptation by coupled stimuli.Nature communications · 2024Article
- Genetically Fusing Order-Promoting and Thermoresponsive Building Blocks to Design Hybrid Biomaterials.Chemistry (Weinheim an der Bergstrasse, Germany) · 2024Review
- Tuning Peptide-Based Nanofibers for Achieving Selective Doxorubicin Delivery in Triple-Negative Breast Cancer.International journal of nanomedicine · 2024Article
- Navigating the Expansive Landscapes of Soft Materials: A User Guide for High-Throughput Workflows.ACS polymers Au · 2023Review
- Biomimetic Sequence-Templating Approach toward a Multiscale Modulation of Chromogenic Polymer Properties.Macromolecules · 2023Article
- Multi-chiral materials comprising metallosupramolecular and covalent helical polymers containing five axial motifs within a helix.Nature communications · 2023Article
- Curcumin-Loaded Self-Assembly Constructed by Octenylsuccinate Fish (Foods (Basel, Switzerland) · 2022Article
- Expanding the Scope of Metastable Species in Hydrogen Bonding-Directed Supramolecular Polymerization.Angewandte Chemie (International ed. in English) · 2022Article
- Control over Multiple Nano- and Secondary Structures in Peptide Self-Assembly.Angewandte Chemie (International ed. in English) · 2022Article
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Authors and funding
6 authors.
Funding
Abstract
Herein, we report the rich morphological and conformational versatility of a biologically active peptide (PEP-1), which follows diverse self-assembly pathways to form up to six distinct nanostructures and up to four different secondary structures through subtle modulation in pH, concentration and temperature. PEP-1 forms twisted β-sheet secondary structures and nanofibers at pH 7.4, which transform into fractal-like structures with strong β-sheet conformations at pH 13.0 or short disorganized elliptical aggregates at pH 5.5. Upon dilution at pH 7.4, the nanofibers with twisted β-sheet secondary structural elements convert into nanoparticles with random coil conformations. Interestingly, these two self-assembled states at pH 7.4 and room temperature are kinetically controlled and undergo a further transformation into thermodynamically stable states upon thermal annealing: whereas the twisted β-sheet structures and corresponding nanofibers transform into 2D sheets with well-defined β-sheet domains, the nanoparticles with random coil structures convert into short nanorods with α-helix conformations. Notably, PEP-1 also showed high biocompatibility, low hemolytic activity and marked antibacterial activity, rendering our system a promising candidate for multiple bio-applications.
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