ArticleNature2022
Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2.
Open access · hybridAbstract read
In one paragraph
Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 292 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
292citing papers in PubMed, 1 pooled it
22.8field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
292 citing papers in PubMed, 1 synthesis or guideline pooled it, 413 citations in OpenAlex.
- A systemic review of T-cell epitopes defined from the proteome of SARS-CoV-2.Virus research · 2023Pooled it
- A gold nanoparticle/peptide vaccine designed to induce SARS-CoV-2-specific CD8 T cells: a double-blind, randomized, phase 1 study in Switzerland.BMC infectious diseases · 2025Trial
- Vaccine-induced T cell responses control Orthoflavivirus challenge infection without neutralizing antibodies in humans.Nature microbiology · 2025Trial
- Reassessing Early COVID-19 Strategies in East Asia: Insights From Japan and Korea.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2026Review
- Lung mucosal and systemic responses at single-cell resolution in an aerosolized Mycobacterium bovis BCG human challenge model.Cell reports. Medicine · 2026Article
- CD4Nature immunology · 2026Article
- Discordant Outcomes of SARS-CoV-2 Exposure in Household Contacts.Clinical immunology communications · 2026Article
- Comprehensive longitudinal profiling identifies differential frequency, epitope specificity, and effector function of CD8EBioMedicine · 2026Article
- Abortive infection: T cells as early, antibody-independent defenders.Nature reviews. Immunology · 2026Article
- Immunological memory to vaccines.Immunity · 2026Review
- Article
- Extensive evolution and T cell escape by SARS-CoV-2 in a 2.5-year persistent infection of an immunocompromised host.iScience · 2026Article
- CEI: A Clonal Expansion Identifier for T-cell receptor clones following SARS-CoV-2 vaccination.ArXiv · 2026Article
- A Roadmap Towards the Identification and Validation of Conserved T Cell Epitope Regions in Viral Pathogen Families with Pandemic Potential.Current pharmaceutical biotechnology · 2026Article
- IFI27-mediated regulation of regulatory T cells aggravates lung injury in sepsis via IL-10/STAT3 signaling.Frontiers in immunology · 2026Article
- Proteome-wide curation of experimentally validated HPV T-cell epitopes identifies key gaps in our understanding of cellular immunity to HPV and informs vaccine design.Frontiers in immunology · 2026Article
- Pre-existing and early cellular immune factors correlate with functionally complete protection against primary controlled human SARS-CoV-2 infection.Nature communications · 2025Article
- Perspective Overview of Changing Population Immunity to COVID-19 in the Context of Infection, Vaccination, and Emerging SARS-CoV-2 Variants.Pathogens (Basel, Switzerland) · 2025Review
- The seven enigmas of SARS-CoV-2: from the past to the future.Journal of human immunity · 2025Article
- Heterologous immunity and antibody-dependent enhancement in respiratory virus infections.Molecular biology reports · 2025Review
232 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
36 authors at 15 institutions in 4 countries.
Leo SwadlingDivision of Infection and Immunity, University College London, London, UK. l.swadling@ucl.ac.uk.ORCID http://orcid.org/0000-0002-0537-6715
Mariana O Diniz *Division of Infection and Immunity, University College London, London, UK.
Nathalie M Schmidt *Division of Infection and Immunity, University College London, London, UK.ORCID http://orcid.org/0000-0002-9841-8418
Oliver E Amin *Division of Infection and Immunity, University College London, London, UK.
Aneesh Chandran *Division of Infection and Immunity, University College London, London, UK.
Emily Shaw *Division of Infection and Immunity, University College London, London, UK.
Corinna PadeBlizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Joseph M GibbonsBlizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.ORCID http://orcid.org/0000-0002-7238-2381
Nina Le BertEmerging Infectious Diseases Program, Duke-NUS Medical School, Singapore, Singapore.ORCID http://orcid.org/0000-0003-0502-2527
Anthony T TanEmerging Infectious Diseases Program, Duke-NUS Medical School, Singapore, Singapore.
Anna Jeffery-SmithDivision of Infection and Immunity, University College London, London, UK.
Cedric C S TanUCL Genetics Institute, University College London, London, UK.
Christine Y L ThamEmerging Infectious Diseases Program, Duke-NUS Medical School, Singapore, Singapore.ORCID http://orcid.org/0000-0002-2913-7591
Stephanie KucykowiczDivision of Infection and Immunity, University College London, London, UK.ORCID http://orcid.org/0000-0002-8849-218X
Gloryanne Aidoo-MicahDivision of Infection and Immunity, University College London, London, UK.
Joshua RosenheimDivision of Infection and Immunity, University College London, London, UK.ORCID http://orcid.org/0000-0003-0171-2053
Jessica DaviesDivision of Infection and Immunity, University College London, London, UK.
Marina JohnsonGreat Ormond Street Institute of Child Health NIHR Biomedical Research Centre, University College London, London, UK.
Melanie P JensenBarts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK.
George JoyBarts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK.
Laura E McCoyDivision of Infection and Immunity, University College London, London, UK.ORCID http://orcid.org/0000-0001-9503-7946
Ana M ValdesAcademic Rheumatology, Clinical Sciences, Nottingham City Hospital, Nottingham, UK.ORCID http://orcid.org/0000-0003-1141-4471
Benjamin M ChainDivision of Infection and Immunity, University College London, London, UK.ORCID http://orcid.org/0000-0002-7417-3970
David GoldblattGreat Ormond Street Institute of Child Health NIHR Biomedical Research Centre, University College London, London, UK.ORCID http://orcid.org/0000-0002-0769-5242
Daniel M AltmannDepartment of Immunology and Inflammation, Imperial College London, London, UK.
Rosemary J BoytonDepartment of Infectious Disease, Faculty of Medicine, Imperial College London, London, UK.ORCID http://orcid.org/0000-0002-5608-0797
Charlotte ManistyBarts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK.
Thomas A TreibelBarts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK.
James C MoonBarts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK.
COVIDsortium Investigators
Lucy van DorpUCL Genetics Institute, University College London, London, UK.ORCID http://orcid.org/0000-0002-6211-2310
Francois BallouxUCL Genetics Institute, University College London, London, UK.ORCID http://orcid.org/0000-0003-1978-7715
Áine McKnightBlizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Mahdad NoursadeghiDivision of Infection and Immunity, University College London, London, UK.ORCID http://orcid.org/0000-0002-4774-0853
Antonio BertolettiEmerging Infectious Diseases Program, Duke-NUS Medical School, Singapore, Singapore.ORCID http://orcid.org/0000-0002-2942-0485
Mala K MainiDivision of Infection and Immunity, University College London, London, UK. m.maini@ucl.ac.uk.ORCID http://orcid.org/0000-0001-6384-1462
St Bartholomew's Hospital · GBUniversity College London · GBQueen Mary University of London · GBAgency for Science, Technology and Research · SGPublic Health England · GBDuke-NUS Medical School · SGMedway School of Pharmacy · GBRoyal Free London NHS Foundation Trust · GBEast London NHS Foundation Trust · GBGuy's and St Thomas' NHS Foundation Trust · GBImperial College London · GBInstitute of Infection and Immunity · CANottingham University Hospitals NHS Trust · GBThe London College · GBUniversity of Cambridge · GB
Funding
British Heart Foundation FS/18/21/33447British Heart Foundation FS/CRTF/21/24128Cancer Research UK 26603Medical Research Council MC_PC_20031Medical Research Council MC_PC_20060Medical Research Council MR/R008698/1Medical Research Council MR/R02622X/1Medical Research Council MR/S019553/1Medical Research Council MR/V027883/1Medical Research Council MR/V036939/1Medical Research Council MR/W020610/1MRF_ MRF-044-0001-RG-SWADLWellcome TrustWellcome Trust 207511/Z/17/ZWellcome Trust 214191/Z/18/Z
Abstract
Individuals with potential exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) do not necessarily develop PCR or antibody positivity, suggesting that some individuals may clear subclinical infection before seroconversion. T cells can contribute to the rapid clearance of SARS-CoV-2 and other coronavirus infections
Indexed as
Asymptomatic InfectionsSeroconversionCell ProliferationCohort StudiesCOVID-19DNA-Directed RNA PolymerasesEvolution, MolecularFemaleHealth PersonnelHumansMaleMembrane ProteinsMemory T CellsMultienzyme ComplexesSARS-CoV-2Transcription, GeneticDNA-Directed RNA PolymerasesIFI27 protein, humanMembrane ProteinsMultienzyme Complexes
Identifiers
What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.