ArticleCell reports2021
Mapping the evolution of T cell states during response and resistance to adoptive cellular therapy.
Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 57 citations in OpenAlex.
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- Single-cell and spatial profiling in cancer biology and clinical oncology.Nature cancer · 2026Review
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- Single-cell insights into the role of T cells in B-cell malignancies.FEBS letters · 2025Review
- Clinical and molecular dissection of CAR T cell resistance in pancreatic cancer.Cell reports. Medicine · 2025Article
- Joint representation and visualization of derailed cell states with Decipher.Genome biology · 2025Article
- A variational deep-learning approach to modeling memory T cell dynamics.PLoS computational biology · 2025Article
- Leveraging transcription factor physical proximity for enhancing gene regulation inference.Bioinformatics (Oxford, England) · 2025Article
- Systematic identification of minor histocompatibility antigens predicts outcomes of allogeneic hematopoietic cell transplantation.Nature biotechnology · 2025Article
- The Bidirectional Interplay between T Cell-Based Immunotherapies and the Tumor Microenvironment.Cancer immunology research · 2025Review
- A variational deep-learning approach to modeling memory T cell dynamics.bioRxiv : the preprint server for biology · 2025Article
- Starfysh integrates spatial transcriptomic and histologic data to reveal heterogeneous tumor-immune hubs.Nature biotechnology · 2025Article
- Coordinated immune networks in leukemia bone marrow microenvironments distinguish response to cellular therapy.Science immunology · 2025Article
- Organ-on-chip for advancing CAR therapy.Clinical & translational immunology · 2025Review
- A Bayesian framework for inferring dynamic intercellular interactions from time-series single-cell data.Genome research · 2024Article
- GPR56 in GVL: marker or mechanism?Blood · 2024Article
- Making drugs from T cells: The quantitative pharmacology of engineered T cell therapeutics.NPJ systems biology and applications · 2024Article
- Article
- Integrating single-cell multi-omics and prior biological knowledge for a functional characterization of the immune system.Nature immunology · 2024Review
Corrections and comments
- Erratum issued
Authors and funding
22 authors at 6 institutions in 1 country.
Funding
Abstract
To elucidate mechanisms by which T cells eliminate leukemia, we study donor lymphocyte infusion (DLI), an established immunotherapy for relapsed leukemia. We model T cell dynamics by integrating longitudinal, multimodal data from 94,517 bone marrow-derived single T cell transcriptomes in addition to chromatin accessibility and single T cell receptor sequencing from patients undergoing DLI. We find that responsive tumors are defined by enrichment of late-differentiated T cells before DLI and rapid, durable expansion of early differentiated T cells after treatment, highly similar to "terminal" and "precursor" exhausted subsets, respectively. Resistance, in contrast, is defined by heterogeneous T cell dysfunction. Surprisingly, early differentiated T cells in responders mainly originate from pre-existing and novel clonotypes recruited to the leukemic microenvironment, rather than the infusion. Our work provides a paradigm for analyzing longitudinal single-cell profiling of scenarios beyond adoptive cell therapy and introduces Symphony, a Bayesian approach to infer regulatory circuitry underlying T cell subsets, with broad relevance to exhaustion antagonists across cancers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.