ArticleCell reports2021
Sox6 expression distinguishes dorsally and ventrally biased dopamine neurons in the substantia nigra with distinctive properties and embryonic origins.
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Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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58 citing papers in PubMed, 94 citations in OpenAlex.
- A population of dopaminergic neurons in the substantia nigra is required for food-anticipatory activity.Current biology : CB · 2026Article
- Engineering functional ventral midbrain dopaminergic neurons in human organoids through WNT modulation and bioreactor culture.Molecular psychiatry · 2026Article
- Calbindin stratifies midbrain dopaminergic neurons governing distinct aspects of locomotion.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Leucine-rich repeat kinase 2 impairs the release sites of Parkinson's disease vulnerable dopamine axons.Nature communications · 2026Article
- The applications of single-cell and spatial transcriptomics in neuroscience and brain disorders.Neuroscience and biobehavioral reviews · 2026Review
- POINTseq: Cell-type-specific barcoding reveals single-cell projection architecture of the mouse dopaminergic system.Neuron · 2026Article
- Sex-Dependent Effects of Glutamatergic Disruption on Dopaminergic Neuron Subtype Vulnerable in Parkinson's Disease.bioRxiv : the preprint server for biology · 2026Article
- Cell type-specific barcoding reveals the single-neuron projectional architecture of the mouse midbrain dopaminergic system.bioRxiv : the preprint server for biology · 2026Article
- Genetic Identification of Dopamine Neurons Required for Circadian Food Anticipatory Activity in Mice.bioRxiv : the preprint server for biology · 2026Article
- Single-cell transcriptomics revealed molecular vulnerability in a human midbrain-like organoid model of Parkinson's disease.iScience · 2026Article
- MiniPromoters Ple384 (TH) and Ple388 (PITX3) for targeting midbrain dopaminergic neurons in mice and monkeys.Scientific reports · 2026Article
- Developmental dopamine loss rewires striatal circuits to promote locomotion.Molecular neurodegeneration · 2026Article
- Parkinsonism Reversal and Dopaminergic Resilience: Lessons from a Rotenone-induced Parkinson's Disease Model.bioRxiv : the preprint server for biology · 2025Article
- Recruitment of specific dopamine neuron sub-circuits by opioids.Addiction neuroscience · 2025Article
- Rapid generation of ventral A9-like dopaminergic neurons from patterned iPSCs.bioRxiv : the preprint server for biology · 2025Article
- LRRK2 and the fragile synapse: a molecular prelude to Parkinson's disease?The Biochemical journal · 2025Review
- Dysfunction of subthalamic dopaminergic circuitry contributes to anxiety- and depression-like behaviors in 6-OHDA lesion-induced hemiparkinsonian mice.Acta pharmacologica Sinica · 2025Article
- Developmental Dopamine Loss Rewires Striatal Circuits to Promote Locomotion.Research square · 2025Article
- Leucine-rich repeat kinase 2 impairs the release sites of Parkinson's disease vulnerable dopamine axons.bioRxiv : the preprint server for biology · 2025Article
- Postsynaptic adaptations in direct pathway muscarinic M4-receptor signaling follow the temporal and regional pattern of dopaminergic degeneration.NPJ Parkinson's disease · 2025Article
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Authors and funding
17 authors at 3 institutions in 2 countries.
Milagros Pereira LuppiDepartment of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Maite AzcorraDepartment of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA; Department of Neurobiology, Northwestern University, Evanston, IL, USA.
Giuliana Caronia-BrownDepartment of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Jean-Francois PoulinDepartment of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA; Montreal Neurological Institute, McGill University, Montreal, QC, Canada.
Zachary GaertnerDepartment of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Serafin GaticaDepartment of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Oscar Andrés Moreno-RamosDepartment of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Navid NouriDepartment of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Marilyn DuboisDepartment of Psychiatry and Neuroscience, Faculty of Medicine, Université Laval, Québec, QC, Canada.
Yongchao C MaDepartment of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Charu RamakrishnanDepartment of Bioengineering, Stanford University School of Medicine, Stanford, CA, USA.
Lief FennoDepartment of Bioengineering, Stanford University School of Medicine, Stanford, CA, USA.
Yoon Seok KimDepartment of Bioengineering, Stanford University School of Medicine, Stanford, CA, USA.
Karl DeisserothDepartment of Bioengineering, Stanford University School of Medicine, Stanford, CA, USA.
Francesca CicchettiDepartment of Psychiatry and Neuroscience, Faculty of Medicine, Université Laval, Québec, QC, Canada.
Daniel A DombeckDepartment of Neurobiology, Northwestern University, Evanston, IL, USA. Electronic address: d-dombeck@northwestern.edu.
Rajeshwar AwatramaniDepartment of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. Electronic address: r-awatramani@northwestern.edu.
Northwestern University · USStanford University · USUniversité Laval · CA
Funding
Rodent Behavior CoreP50DA044121 · NIDA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI RADULOVIC, JELENA · 2018 to 2022
$9.0MIntegrative genomics to map risk genes and pathways in autism and epilepsyR01MH110555 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI PINTO, DALILA · 2016 to 2020
$3.9MMolecular, anatomic, and functional characterization of midbrain dopamine neuron subtypesR01MH110556 · NIMH · NORTHWESTERN UNIVERSITY · PI AWATRAMANI, RAJESHWAR B, DOMBECK, DANIEL A · 2017 to 2021
$3.5MRational derivation of DA neuron subtypes from iPS cells for improved modelling of Parkinson's diseaseR01NS096240 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI AWATRAMANI, RAJESHWAR B, KRAINC, DIMITRI · 2016 to 2020
$3.0MDevelopmental underpinnings of substantia nigra vulnerabilityR01NS119690 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI AWATRAMANI, RAJESHWAR B · 2021 to 2025
$2.4MGenetic tools to study CNS development and functionR21NS092034 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI AWATRAMANI, RAJESHWAR B · 2015 to 2016
$425kAging Stress Pathway and Dopaminergic Neuron Degeneration in Parkinson's DiseaseR21AG043970 · NIA · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI MA, YONGCHAO CHARLES · 2013 to 2014
$393kThe role of transcription factor SOX6 in midbrain dopamine neuron lineage and molecular diversityF31NS122481 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI PEREIRA LUPPI, MARIA MILAGROS · 2021 to 2022
$80kNIA NIH HHS R21 AG043970NIDA NIH HHS P50 DA044121NIMH NIH HHS R01 MH110555NIMH NIH HHS R01 MH110556NINDS NIH HHS F31 NS122481NINDS NIH HHS R01 NS096240NINDS NIH HHS R01 NS119690NINDS NIH HHS R21 NS092034
Abstract
Dopamine (DA) neurons in the ventral tier of the substantia nigra pars compacta (SNc) degenerate prominently in Parkinson's disease, while those in the dorsal tier are relatively spared. Defining the molecular, functional, and developmental characteristics of each SNc tier is crucial to understand their distinct susceptibility. We demonstrate that Sox6 expression distinguishes ventrally and dorsally biased DA neuron populations in the SNc. The Sox6
Indexed as
Gene Expression Regulation, DevelopmentalAgedAged, 80 and overAnimalsCase-Control StudiesCorpus StriatumDopamineDopaminergic NeuronsFemaleHumansMaleMiceMice, Inbred C57BLMice, KnockoutMiddle AgedParkinson DiseaseDopamineSOX6 protein, humanSox6 protein, mouseSOXD Transcription FactorsAldh1a1Calb1dopaminedorsal SNcfate mapParkinson’sselective vulnerabilitySox6ventral SNc
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