ArticleCell reports2021
Temporal dynamics of persistent germinal centers and memory B cell differentiation following respiratory virus infection.
Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 46 citations in OpenAlex.
- Isotype-specific antibody secreting plasma cells harbor epigenetic and transcription factor architectures defining distinct cell lineages.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Human immune response to primary cryptosporidiosis parallels murine infection models.Infection and immunity · 2026Article
- Nanoparticle Immunoadjuvant Complexes Augment Germinal Center Responses to Vaccination.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The multilayered identity of B cell memory.Cellular & molecular immunology · 2026Review
- Tumor immune microenvironment in non-small cell lung cancer progression.Frontiers in immunology · 2026Review
- Article
- B lymphocytes that enter the germinal center late preferentially differentiate into memory cells that recognize subdominant epitopes.bioRxiv : the preprint server for biology · 2025Article
- Article
- EZH2 coordinates memory B-cell programming and recall responses.Journal of immunology (Baltimore, Md. : 1950) · 2025Article
- Multi-strain modeling of influenza vaccine effectiveness in older adults and its dependence on antigenic distance.Scientific reports · 2024Article
- Gastrointestinal germinal center B cell depletion and reduction in IgAScience immunology · 2024Article
- Article
- CD62L expression marks a functionally distinct subset of memory B cells.Cell reports · 2023Article
- SARS-CoV-2 reservoir in post-acute sequelae of COVID-19 (PASC).Nature immunology · 2023Review
- ePlatypus: an ecosystem for computational analysis of immunogenomics data.Bioinformatics (Oxford, England) · 2023Article
- Germline-encoded specificities and the predictability of the B cell response.PLoS pathogens · 2023Article
- Distinct metabolic requirements regulate B cell activation and germinal center responses.Nature immunology · 2023Article
- 'Persistent germinal center responses: slow-growing trees bear the best fruits'.Current opinion in immunology · 2023Review
- B-Cell Responses in Chronic Chagas Disease: Waning of Trypanosoma cruzi-Specific Antibody-Secreting Cells Following Successful Etiological Treatment.The Journal of infectious diseases · 2023Article
- The function of γδ T cells in humoral immune responses.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
Abstract
Following infection or immunization, memory B cells (MBCs) and long-lived plasma cells provide humoral immunity that can last for decades. Most principles of MBC biology have been determined with hapten-protein carrier models or fluorescent protein immunizations. Here, we examine the temporal dynamics of the germinal center (GC) B cell and MBC response following mouse influenza A virus infection. We find that antiviral B cell responses within the lung-draining mediastinal lymph node (mLN) and the spleen are distinct in regard to duration, enrichment for antigen-binding cells, and class switching dynamics. While splenic GCs dissolve after 6 weeks post-infection, mLN hemagglutinin-specific (HA
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.