Evidence map›Paper›PMID 34758304›Full record

ArticleCell reports2021

Distinct in vivo dynamics of excitatory synapses onto cortical pyramidal neurons and parvalbumin-positive interneurons.

Joshua B Melander, Aran Nayebi, Bart C Jongbloets, Dale A Fortin, Maozhen Qin, Surya Ganguli, Tianyi Mao, Haining Zhong

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 24 citations in OpenAlex.

  1. Sex- and experience-dependent regulation of synaptic protein turnover.Proceedings of the National Academy of Sciences of the United States of America · 2026
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  5. Sensitive and Selective Next-Generation FRET-based PKA Biosensors.bioRxiv : the preprint server for biology · 2026
    Article
  6. Article
  7. Sex and experience dependent regulation of synaptic protein turnover.bioRxiv : the preprint server for biology · 2025
    Article
  8. Article
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  11. Differential nanoscale organization of excitatory synapses onto excitatory vs. inhibitory neurons.Proceedings of the National Academy of Sciences of the United States of America · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Joshua B MelanderVollum Institute, Oregon Health & Science University, Portland, OR 97239, USA; Neurosciences PhD Program, Stanford University, Stanford, CA 94305, USA.
Aran NayebiNeurosciences PhD Program, Stanford University, Stanford, CA 94305, USA.
Bart C JongbloetsVollum Institute, Oregon Health & Science University, Portland, OR 97239, USA.
Dale A FortinVollum Institute, Oregon Health & Science University, Portland, OR 97239, USA.
Maozhen QinVollum Institute, Oregon Health & Science University, Portland, OR 97239, USA.
Surya GanguliDepartment of Applied Physics, Stanford University, Stanford, CA 94305, USA. Electronic address: sganguli@stanford.edu.
Tianyi MaoVollum Institute, Oregon Health & Science University, Portland, OR 97239, USA. Electronic address: mao@ohsu.edu.
Haining ZhongVollum Institute, Oregon Health & Science University, Portland, OR 97239, USA. Electronic address: zhong@ohsu.edu.
Oregon Health & Science University · USStanford Medicine · USStanford University · US

Funding

Multiplex imaging of neuronal activity and signaling dynamics underlying learning in discrete amygdala circuits of behaving mice.R01NS104944 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI LI, BO, MAO, TIANYI · 2018 to 2022
$5.0M
Genetic and physiological dissection of the circuit mechanisms in the striatum.R01NS081071 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI MAO, TIANYI · 2013 to 2023
$3.6M
Cell-Specific Visualization of Endogenous ProteinsRF1MH120119 · NIMH · OREGON HEALTH & SCIENCE UNIVERSITY · PI MAO, TIANYI, ZHONG, HAINING · 2019 to 2019
$2.8M
A novel approach to examine slow synaptic transmission in vivoU01NS094247 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI MAO, TIANYI, ZHONG, HAINING · 2015 to 2018
$1.3M
Fluorescence labeling of PSD-95 at endogenous levels for single cell imagingR21NS084315 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI ZHONG, HAINING · 2014 to 2015
$424k
Fluorescence labeling of synaptic proteins for cell-specific imaging in vivoR21NS097856 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI ZHONG, HAINING · 2016 to 2017
$424k
NIMH NIH HHS RF1 MH120119NINDS NIH HHS R01 NS081071NINDS NIH HHS R01 NS104944NINDS NIH HHS R21 NS084315NINDS NIH HHS R21 NS097856NINDS NIH HHS U01 NS094247
6 · The paper itself

Abstract

Cortical function relies on the balanced activation of excitatory and inhibitory neurons. However, little is known about the organization and dynamics of shaft excitatory synapses onto cortical inhibitory interneurons. Here, we use the excitatory postsynaptic marker PSD-95, fluorescently labeled at endogenous levels, as a proxy for excitatory synapses onto layer 2/3 pyramidal neurons and parvalbumin-positive (PV

Indexed as

Neural InhibitionAnimalsDisks Large Homolog 4 ProteinExcitatory Postsynaptic PotentialsFemaleInterneuronsMaleMiceMice, Inbred C57BLMice, KnockoutNeuronal PlasticityParvalbuminsPyramidal CellsSynapsesDisks Large Homolog 4 ProteinDlg4 protein, mouseParvalbuminsadditive and multiplicative synaptic dynamicsin vivo two-photon imaginglog normalityMarkov modelparvalbumin-positive inhibitory interneuronPSD-95shaft excitatory synapsesstructural plasticitysynaptic weight

Identifiers

PMID34758304
PMCPMC8631347
OpenAlexW3212710578

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.