ArticleCell reports2021
The hepatic compensatory response to elevated systemic sulfide promotes diabetes.
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Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14citing papers in PubMed
2.2field-weighted citation impact, top 14% of its field
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Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- Cinnamic acid attenuates Klebsiella pneumoniae virulence by suppressing capsule biosynthesis.Archives of pharmacal research · 2026Article
- Hydrogen Sulfide Signaling in Neurodegenerative Movement Disorders.Handbook of experimental pharmacology · 2026Review
- Metabolic dysfunction-associated steatohepatitis reduces hepatic HRedox biology · 2025Article
- Transcriptomic Analysis of the Liver Redox Response During Food-Anticipatory Activity Under a Time-Restricted Feeding Protocol in Rats.Antioxidants (Basel, Switzerland) · 2025Article
- Thiosulphate sulfurtransferase: Biological roles and therapeutic potential.Redox biology · 2025Review
- The Role of Bacteria-Derived Hydrogen Sulfide in Multiple Axes of Disease.International journal of molecular sciences · 2025Review
- Essential role of sulfide oxidation in brain health and neurological disorders.Pharmacology & therapeutics · 2025Review
- Deficiency of thiosulfate sulfurtransferase mediates the dysfunction of renal tubular mitochondrial fatty acid oxidation in diabetic kidney disease.Cell death and differentiation · 2024Article
- Mining proteomes for zinc finger persulfidation.RSC chemical biology · 2024Article
- Thiosulfate sulfurtransferase deficiency promotes oxidative distress and aberrant NRF2 function in the brain.Redox biology · 2023Article
- Hepatic hydrogen sulfide levels are reduced in mouse model of Hutchinson-Gilford progeria syndrome.Aging · 2023Article
- Function of gaseous hydrogen sulfide in liver fibrosis.BMB reports · 2022Review
- Cysteine as a Multifaceted Player in Kidney, theMolecules (Basel, Switzerland) · 2022Review
- Sulfurtransferases and Cystathionine Beta-Synthase Expression in Different Human Leukemia Cell Lines.Biomolecules · 2022Article
Corrections and comments
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Authors and funding
29 authors at 9 institutions in 5 countries.
Roderick N CarterUniversity/British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Queen's Medical Research Institute, Edinburgh EH16 4TJ, UK.
Matthew T G GibbinsUniversity/British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Queen's Medical Research Institute, Edinburgh EH16 4TJ, UK.
Martin E Barrios-LlerenaUniversity/British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Queen's Medical Research Institute, Edinburgh EH16 4TJ, UK.
Stephen E WilkieUniversity/British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Queen's Medical Research Institute, Edinburgh EH16 4TJ, UK; Glasgow Ageing Research Network (GARNER), Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, Glasgow G12 8QQ, UK.
Lydia FreddolinoDepartment of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Marouane LibiadDepartment of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Victor VitvitskyDepartment of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Barry EmersonUniversity/British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Queen's Medical Research Institute, Edinburgh EH16 4TJ, UK.
Thierry Le BihanSynthSys - Systems and Synthetic Biology, Edinburgh EH9 3JD, UK.
Madara BriceUniversity/British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Queen's Medical Research Institute, Edinburgh EH16 4TJ, UK.
Huizhong SuCancer Research UK Edinburgh Centre, MRC Institute of Genetics & Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XR, UK.
Scott G DenhamUniversity/British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Queen's Medical Research Institute, Edinburgh EH16 4TJ, UK.
Natalie Z M HomerUniversity/British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Queen's Medical Research Institute, Edinburgh EH16 4TJ, UK.
Clare Mc FaddenUniversity/British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Queen's Medical Research Institute, Edinburgh EH16 4TJ, UK.
Anne TailleuxUniversité de Lille, INSERM, CHU Lille, Institut Pasteur de Lille, U101-EGID, 59000, Lille, France.
Nourdine FaressePhysiogenex S.A.S, Prologue Biotech, 516 rue Pierre et Marie Curie, 31670 Labège, France.
Thierry SulpicePhysiogenex S.A.S, Prologue Biotech, 516 rue Pierre et Marie Curie, 31670 Labège, France.
Francois BriandPhysiogenex S.A.S, Prologue Biotech, 516 rue Pierre et Marie Curie, 31670 Labège, France.
Tom GillingwaterCollege of Medicine & Veterinary Medicine, University of Edinburgh, Old Medical School (Anatomy), Teviot Place, Edinburgh EH8 9AG, UK.
Kyo Han AhnDepartment of Chemistry, POSTECH, 77 Cheongam-Ro, Nam-Gu, Pohang, Gyungbuk 37673, South Korea.
Subhankar SinghaDepartment of Chemistry, POSTECH, 77 Cheongam-Ro, Nam-Gu, Pohang, Gyungbuk 37673, South Korea.
Claire McMasterSchool of Chemistry, Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, UK.
Richard C HartleySchool of Chemistry, Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, UK.
Bart StaelsUniversité de Lille, INSERM, CHU Lille, Institut Pasteur de Lille, U101-EGID, 59000, Lille, France.
Gillian A GrayUniversity/British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Queen's Medical Research Institute, Edinburgh EH16 4TJ, UK.
Andrew J FinchCancer Research UK Edinburgh Centre, MRC Institute of Genetics & Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XR, UK.
Colin SelmanGlasgow Ageing Research Network (GARNER), Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, Glasgow G12 8QQ, UK.
Ruma BanerjeeDepartment of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Nicholas M MortonUniversity/British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Queen's Medical Research Institute, Edinburgh EH16 4TJ, UK. Electronic address: nik.morton@ed.ac.uk.
British Heart Foundation · GBUniversity of Michigan · USPhysiogenex (France) · FRUniversity of Glasgow · GBInserm · FRPohang University of Science and Technology · KRWestern General Hospital · GBSynopsys (Switzerland) · CHUniversity of Edinburgh · GB
Funding
Sulfide Oxidation and SignalingR35GM130183 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RUMA V BANERJEE · 2019 to 2026
$3.6MDiabetes UK 17/0005697Medical Research Council MC-PC-15076Medical Research Council MC_PC_15076NIGMS NIH HHS R35 GM130183Wellcome TrustWellcome Trust 100981/Z/13/Z
Abstract
Impaired hepatic glucose and lipid metabolism are hallmarks of type 2 diabetes. Increased sulfide production or sulfide donor compounds may beneficially regulate hepatic metabolism. Disposal of sulfide through the sulfide oxidation pathway (SOP) is critical for maintaining sulfide within a safe physiological range. We show that mice lacking the liver- enriched mitochondrial SOP enzyme thiosulfate sulfurtransferase (Tst
Indexed as
GluconeogenesisAnimalsDiabetes MellitusDyslipidemiasGlucoseLipid MetabolismLiverMaleMiceMice, Inbred C57BLMice, KnockoutNF-E2-Related Factor 2ProteomeSulfidesThiosulfate SulfurtransferaseGlucoseNfe2l2 protein, mouseNF-E2-Related Factor 2ProteomeSulfidesThiosulfate Sulfurtransferasefatty livergluconeogenesisinsulin sensitivitypersulfidationsulfidesulfide donorsulfide oxidation pathwaythiosulfate sulfur transferaseTSTtype 2 diabetes
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.