Evidence map›Paper›PMID 34758298›Full record

ArticleCell reports2021

Hippocampal gamma and sharp-wave ripple oscillations are altered in a Cntnap2 mouse model of autism spectrum disorder.

Rosalia Paterno, Joseane Righes Marafiga, Harrison Ramsay, Tina Li, Kathryn A Salvati, Scott C Baraban

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
5.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 67 citations in OpenAlex.

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  7. Complimentary vertebratebioRxiv : the preprint server for biology · 2025
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  9. Functional Alterations in Parvalbumin-Positive Interneurons after Traumatic Brain Injury in Somatosensory Cortex of Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Rosalia PaternoDepartment of Neurological Surgery and Weill Institute of Neuroscience, University of California, San Francisco, CA 94143, USA. Electronic address: rosalia.paterno@ucsf.edu.
Joseane Righes MarafigaNeurophysiology and Neurochemistry of Neuronal Excitability and Synaptic Plasticity Laboratory, Graduate Program in Biological Sciences: Biochemistry, Department of Biochemistry, ICBS, Universidade Federal do Rio Grande do Sul, Porto Alegre, 90035-003, Brazil.
Harrison RamsayDepartment of Neurological Surgery and Weill Institute of Neuroscience, University of California, San Francisco, CA 94143, USA.
Tina LiDepartment of Neurological Surgery and Weill Institute of Neuroscience, University of California, San Francisco, CA 94143, USA.
Kathryn A SalvatiDepartment of Neurological Surgery and Weill Institute of Neuroscience, University of California, San Francisco, CA 94143, USA.
Scott C BarabanDepartment of Neurological Surgery and Weill Institute of Neuroscience, University of California, San Francisco, CA 94143, USA.
University of California, San Francisco · USUniversidade Federal do Rio Grande do Sul · BR

Funding

An Interneuron-based Cell Therapy for EpilepsyR37NS071785 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BARABAN, SCOTT C · 2015 to 2021
$4.4M
NINDS NIH HHS R37 NS071785
6 · The paper itself

Abstract

Impaired synaptic neurotransmission may underly circuit alterations contributing to behavioral autism spectrum disorder (ASD) phenotypes. A critical component of impairments reported in somatosensory and prefrontal cortex of ASD mouse models are parvalbumin (PV)-expressing fast-spiking interneurons. However, it remains unknown whether PV interneurons mediating hippocampal networks crucial to navigation and memory processing are similarly impaired. Using PV-labeled transgenic mice, a battery of behavioral assays, in vitro patch-clamp electrophysiology, and in vivo 32-channel silicon probe local field potential recordings, we address this question in a Cntnap2-null mutant mouse model representing a human ASD risk factor gene. Cntnap2

Indexed as

Gamma RhythmSynaptic TransmissionAction PotentialsAnimalsAutism Spectrum DisorderDisease Models, AnimalHippocampusInterneuronsMaleMembrane ProteinsMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicNerve Tissue ProteinsPyramidal CellsCNTNAP2 protein, mouseMembrane ProteinsNerve Tissue Proteinsautismbiomarkercntnap2EEGgammahippocampusinhibitioninterneuronsoscillationssharp wave ripples

Identifiers

PMID34758298
PMCPMC8783641
OpenAlexW3213091629

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.