Evidence map›Paper›PMID 34758284›Full record

ArticleCurrent biology : CB2022

High viral abundance and low diversity are associated with increased CRISPR-Cas prevalence across microbial ecosystems.

Sean Meaden, Ambarish Biswas, Ksenia Arkhipova, Sergio E Morales, Bas E Dutilh, Edze R Westra, Peter C Fineran

Abstract read
In one paragraph

Article in Current biology : CB, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Article
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  5. Phage defence-system abundances vary across environments and increase with viral density.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Bacteriophages inMicrobial genomics · 2025
    Article
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  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sean MeadenEnvironment and Sustainability Institute, Biosciences, University of Exeter, Penryn TR10 9EZ, UK; Department of Microbiology and Immunology, University of Otago, PO Box 56, Dunedin 9054, New Zealand. Electronic address: s.meaden@exeter.ac.uk.
Ambarish BiswasDepartment of Microbiology and Immunology, University of Otago, PO Box 56, Dunedin 9054, New Zealand; Grasslands Research Centre, AgResearch, PO Box 11008, Palmerston North 4442, New Zealand.
Ksenia ArkhipovaTheoretical Biology and Bioinformatics, Science for Life, Utrecht University, Utrecht, the Netherlands.
Sergio E MoralesDepartment of Microbiology and Immunology, University of Otago, PO Box 56, Dunedin 9054, New Zealand.
Bas E DutilhTheoretical Biology and Bioinformatics, Science for Life, Utrecht University, Utrecht, the Netherlands.
Edze R WestraEnvironment and Sustainability Institute, Biosciences, University of Exeter, Penryn TR10 9EZ, UK.
Peter C FineranDepartment of Microbiology and Immunology, University of Otago, PO Box 56, Dunedin 9054, New Zealand; Bioprotection Aotearoa, University of Otago, PO Box 56, Dunedin 9054, New Zealand.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CRISPR-Cas are adaptive immune systems that protect their hosts against viruses and other parasitic mobile genetic elements.

Indexed as

BacteriophagesCRISPR-Cas SystemsEcosystemMetagenomicsPrevalencebacteriophagesCRISPR-Casmetagenomicsmicrobial ecology

Identifiers

PMID34758284
PMCPMC8751634

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.