Evidence map›Paper›PMID 34758268›Full record

ReviewAnnual review of physiology2022

Mitochondrial H

Ambre M Bertholet, Yuriy Kirichok

Open access · bronzeAbstract readReview
In one paragraph

Review in Annual review of physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 62 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Replenishment of mitochondrial NaMaterials today. Bio · 2024
    Article
  18. Review
  19. PMHeliyon · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Ambre M BertholetDepartment of Physiology, University of California, San Francisco, California, USA; email: yuriy.kirichok@ucsf.edu.
Yuriy KirichokDepartment of Physiology, University of California, San Francisco, California, USA; email: yuriy.kirichok@ucsf.edu.
University of California, San Francisco · US

Funding

UCSF Nutrition Obesity Research CenterP30DK098722 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHRISTIAN VAISSE · 2015 to 2026
$14.6M
Molecular Biophysics of Mitochondrial MembranesR35GM136415 · NIGMS · WASHINGTON UNIVERSITY · PI Yuriy Kirichok · 2020 to 2026
$4.7M
Mechanisms of regulation of mitochondrial H+ leak and thermogenesisR35GM143097 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BERTHOLET, AMBRE MARGUERITE SOLANGE · 2021 to 2025
$1.9M
NIDDK NIH HHS P30 DK098722NIGMS NIH HHS R35 GM136415NIGMS NIH HHS R35 GM143097
6 · The paper itself

Abstract

Mitochondria of all tissues convert various metabolic substrates into two forms of energy: ATP and heat. Historically, the primary focus of research in mitochondrial bioenergetics was on the mechanisms of ATP production, while mitochondrial thermogenesis received significantly less attention. Nevertheless, mitochondrial heat production is crucial for the maintenance of body temperature, regulation of the pace of metabolism, and prevention of oxidative damage to mitochondria and the cell. In addition, mitochondrial thermogenesis has gained significance as a pharmacological target for treating metabolic disorders. Mitochondria produce heat as the result of H

Indexed as

MitochondriaThermogenesisEnergy MetabolismHumansMitochondrial ProteinsUncoupling Protein 1Mitochondrial ProteinsUncoupling Protein 1ADP/ATP carrierH+ leakmitochondriathermogenesisuncouplinguncoupling proteins

Identifiers

PMID34758268
PMCPMC8976115
OpenAlexW3213088770

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.