ArticleEpilepsia open2022
Stereotactic laser interstitial thermal therapy corpus callosotomy for the treatment of pediatric drug-resistant epilepsy.
Article in Epilepsia open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 29 citations in OpenAlex.
- Anatomy of corpus callosum and lateral ventricle: a fiber dissection study.Annals of medicine and surgery (2012) · 2026Article
- Epilepsy: Molecular Pathogenesis and Emerging Therapies.MedComm · 2026Review
- MRI-guided laser ablation for pediatric intracranial pathology: single center experience.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Article
- New insights from MRI-guided laser interstitial thermal therapy for refractory epilepsy: a state-of-the-art overview.Frontiers in surgery · 2026Review
- A Standardized Approach to MRI-Guided Stereotactic Laser Corpus Callosotomy: Technical Description and Pediatric Case Series.Operative neurosurgery (Hagerstown, Md.) · 2025Article
- Comparison of magnetic resonance-guided laser interstitial thermal therapy corpus callosum ablation to open microsurgical corpus callosotomy: A single-center retrospective cohort study.Epilepsia open · 2024Article
- The changing landscape of palliative epilepsy surgery for Lennox Gastaut Syndrome.Frontiers in neurology · 2024Review
- Applications of magnetic resonance-guided laser interstitial thermal therapy in disconnective epilepsy surgery.Frontiers in neurology · 2024Review
- Corpus Callosotomy Is a Safe and Effective Procedure for Medically Resistant Epilepsy.Advances and technical standards in neurosurgery · 2023Article
- Magnetic resonance imaging-guided laser interstitial thermal therapy for complete corpus callosotomy: technique and 1-year outcomes. Patient series.Journal of neurosurgery. Case lessons · 2022Article
- Robot-Assisted Radiofrequency Ablation Combined with Thermodynamic Simulation for Epilepsy Reoperations.Journal of clinical medicine · 2022Article
- Stereotactic laser interstitial thermal therapy for the treatment of pediatric drug-resistant epilepsy: indications, techniques, and safety.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2022Article
- Stereotactic laser interstitial thermal therapy corpus callosotomy for the treatment of pediatric drug-resistant epilepsy.Epilepsia open · 2022Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectiveCorpus callosotomy is a safe and effective procedure for reducing the frequency of drop attacks. MR-guided laser interstitial thermal therapy (MRgLITT) offers a minimally invasive alternative to conventional open craniotomy for callosotomy. We hypothesized that MRgLITT callosotomy could be safely performed in pediatric patients with similar seizure control.
methodsWe present an institutional case series of 11 procedures in 10 patients for the treatment of drop attacks in drug-refractory primary generalized epilepsy. MRgLITT was used for complete callosotomy, anterior two-thirds, posterior, or ablation of residual callosal fibers following prior callosotomy (open or MRgLITT). We retrospectively reviewed clinical course, operative details, radiographic imaging, clinical outcomes, and complications.
resultsOperative time ranged from 4-8 hours, and median hospitalization was 2 days. No complications were encountered. Among the 7 patients with at least 3 months of follow-up, 71% experienced freedom from drop attacks at longest follow-up and 57% of cases showed improvement in their other seizure semiologies as well (Engel Class II: 28%, Class III: 28%, Class IV: 43%). SIGNIFICANCE: MR-guided LITT callosotomy is safe and effective modality in the management of pediatric patients with medically intractable epilepsy characterized by drop attacks. While this is among the largest pediatric series to date, further studies are required to delineate its safety and efficacy among such patients.
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