Evidence map›Paper›PMID 34758110›Full record

ArticleActa psychiatrica Scandinavica2022

Does cannabis use in adolescence predict self-harm or suicide? Results from a Finnish Birth Cohort Study.

Alexander Denissoff, Solja Niemelä, James G Scott, Caroline L Salom, Emily Hielscher, Jouko Miettunen, Anni-Emilia Alakokkare, Antti Mustonen

Abstract read
In one paragraph

Article in Acta psychiatrica Scandinavica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Alexander DenissoffDepartment of Psychiatry, Faculty of Medicine, University of Turku, Turku, Finland.
Solja NiemeläDepartment of Psychiatry, Faculty of Medicine, University of Turku, Turku, Finland.
James G ScottQIMR Berghofer Medical Research Institute Herston, Herston, Qld, Australia.ORCID 0000-0002-0744-0688
Caroline L SalomInstitute for Social Science Research, The University of Queensland, Brisbane, Australia.
Emily HielscherQIMR Berghofer Medical Research Institute Herston, Herston, Qld, Australia.
Jouko MiettunenCenter for Life Course Health Research, University of Oulu, Oulu, Finland.
Anni-Emilia AlakokkareDepartment of Psychiatry, Faculty of Medicine, University of Turku, Turku, Finland.
Antti MustonenCenter for Life Course Health Research, University of Oulu, Oulu, Finland.ORCID 0000-0002-3259-2122

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveLongitudinal studies examining the association between adolescent cannabis use and self-harm are rare, heterogeneous and mixed in their conclusions. We study this association utilizing a large general population-based sample with prospective data.

methodsThe Northern Finland Birth Cohort 1986 (n = 6582) with linkage to nationwide register data was used to study the association of self-reported cannabis use at age 15-16 years and self-harm and suicide death until age 33 (until year 2018), based on register information. Cox regression analysis with Hazard Ratios (HR) and 95% confidence intervals (CI) was used. Psychiatric disorders, parental psychiatric disorders and other substance use were considered as confounders.

resultsIn all, 6582 (49.2% male) were included in the analysis, and 377 adolescents (5.7%) reported any cannabis use until the age of 15-16 years. Based on register information, 79 (55.7% male) had visited in health care services due to self-harm, and 22 (90.1% male) had died by suicide. In crude analyses, adolescent cannabis use was associated with self-harm (HR = 3.93; 95% CI 2.24-6.90). The association between cannabis use and self-harm remained statistically significant after adjusting for sex, psychiatric disorders at baseline, frequent alcohol intoxications, other illicit drug use, and parental psychiatric disorders (HR 2.06; 95% CI 1.07-3.95). In contrast, the association of cannabis use with suicide did not reach statistical significance even in crude analysis (HR 2.60; 95% CI 0.77-8.78).

conclusionCannabis use in adolescence may increase risk of self-harm independent of adolescent psychopathology and other substance use.

Indexed as

CannabisSelf-Injurious BehaviorSubstance-Related DisordersSuicideAdolescentAdultBirth CohortCohort StudiesFemaleFinlandHumansMaleProspective StudiesRisk Factorsadolescentbirth cohortcannabisself-harm

Identifiers

PMID34758110
PMCPMC9299098

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.